Molecular pharmacology in a simple model system: implicating MAP kinase and phosphoinositide signalling in bipolar disorder.
Molecular pharmacology in a simple model system: implicating MAP kinase and phosphoinositide signalling in bipolar disorder.
复制标题
DOI：
10.1016/j.semcdb.2010.11.002
复制
发表时间：
2011-02
影响因子：
7.3
通讯作者：
Williams, Robin S. B.
中科院分区：
文献类型：
--
作者：
Ludtmann, Marthe H. R.;Boeckeler, Katrina;Williams, Robin S. B.
Understanding the mechanisms of drug action has been the primary focus for pharmacological researchers, traditionally using rodent models. However, non-sentient model systems are now increasingly being used as an alternative approach to better understand drug action or targets. One of these model systems, the social amoeba Dictyostelium, enables the rapid ablation or over-expression of genes, and the subsequent use of isogenic cell culture for the analysis of cell signalling pathways in pharmacological research. The model also supports an increasingly important ethical view of research, involving the reduction, replacement and refinement of animals in biomedical research. This review outlines the use of Dictyostelium in understanding the pharmacological action of two commonly used bipolar disorder treatments (valproic acid and lithium). Both of these compounds regulate mitogen activated protein (MAP) kinase and inositol phospholipid-based signalling by unknown means. Analysis of the molecular pathways targeted by these drugs in Dictyostelium and translation of discoveries to animal systems has helped to further understand the molecular mechanisms of these bipolar disorder treatments.
登录
查看更多内容
影响因子：
9.2
作者：
Buttery, Neil J.;Rozen, Daniel E.;Thompson, Christopher R. L.
通讯作者：
Thompson, Christopher R. L.
影响因子：
3.8
作者：
Alam, Hasan B.;Shuja, Fahad;Velmahos, George C.
通讯作者：
Velmahos, George C.
影响因子：
11.4
作者：
CADE, JFJ
通讯作者：
CADE, JFJ
影响因子：
5.4
作者：
Breen, G;Harwood, AJ;Williams, RSB
通讯作者：
Williams, RSB
影响因子：
5.6
作者：
Angst, J;Gamma, A;Rössler, W
通讯作者：
Rössler, W