Application of Reduced-FOV Diffusion-Weighted Imaging in Evaluation of Normal Pituitary Glands and Pituitary Macroadenomas
Application of Reduced-FOV Diffusion-Weighted Imaging in Evaluation of Normal Pituitary Glands and Pituitary Macroadenomas
复制标题
缩小视场弥散加权成像在正常垂体和垂体大腺瘤评估中的应用
DOI：
10.3174/ajnr.a5735
复制
发表时间：
2018
影响因子：
3.5
通讯作者：
J. Yang
中科院分区：
文献类型：
--
作者：
M. Wang;H. Liu;X. Wei;C. Liu;T. Liang;X. Zhang;C. Jin;X. Li;Q. Sun;H. Jiang;J. Yang
背景与目的：视场优化和约束的无畸变单镜头成像提供了相对高分辨率的图像，几乎没有伪影。本研究评价视场优化约束无畸变单次DWI对正常垂体及垂体大腺瘤的成像质量及价值。材料与方法：垂体正常受试者和垂体大腺瘤患者行视场优化约束无畸变单摄和EPI DWI。两名神经放射学家根据垂体柄、垂体腺和垂体大腺瘤的可视化对图像质量进行分级。通过κ统计量评估观察者内部和观察者之间的一致性。采用配对Wilcoxon符号秩检验和t检验比较两种方法的图像质量和adc。采用独立样本t检验分析正常垂体与大腺瘤间ADC的差异。结果：纳入垂体正常患者28例，大腺瘤患者16例。对图像质量评估的观察员内部和观察员之间的协议是中等到实质性的。与EPI DWI相比，视场优化约束无畸变单镜头DWI在正常垂体和大腺瘤中均表现出更好的图像质量。两种方法对大腺瘤的adc比较，差异无统计学意义。软一致性大腺瘤（0.75±0.14 × 10−3 mm2/s）的平均ADC明显低于正常垂体（1.18±0.19 × 10−3 mm2/s, P < 0.001）。结论：在临床可行的扫描时间内，优化视场并约束无畸变的单次DWI可以获得正常垂体和垂体大腺瘤的高分辨率图像，且相对较少的敏感性伪影。该序列可能有助于评价垂体大腺瘤的一致性。
BACKGROUND AND PURPOSE: FOV optimized and constrained undistorted single-shot imaging provides relatively high-resolution images with few artifacts. This study evaluated the image quality and value of FOV optimized and constrained undistorted single-shot DWI in the evaluation of normal pituitary glands and pituitary macroadenomas. MATERIALS AND METHODS: Subjects with normal pituitary glands and patients with pituitary macroadenomas underwent FOV optimized and constrained undistorted single-shot and EPI DWI. Two neuroradiologists graded the image quality based on visualization of the pituitary stalk, pituitary gland, and pituitary macroadenoma. Intra- and interobserver agreements were assessed by κ statistics. Image quality and ADCs were compared between the 2 methods by the paired Wilcoxon signed rank test and t test. Differences in ADC between normal pituitary glands and macroadenomas were analyzed by the independent-samples t test. RESULTS: Twenty-eight subjects with normal pituitary glands and 16 patients with macroadenomas were enrolled. Intra- and interobserver agreements for image-quality assessment were moderate to substantial. Relative to EPI DWI, FOV optimized and constrained undistorted single-shot DWI exhibited obviously better image quality both in normal pituitary glands and macroadenomas. There was no significant difference in ADCs of macroadenomas between the 2 methods. Macroadenomas with soft consistency (0.75 ± 0.14 × 10−3 mm2/s) had significantly lower mean ADC than normal pituitary glands (1.18 ± 0.19 × 10−3 mm2/s; P < .001). CONCLUSIONS: FOV optimized and constrained undistorted single-shot DWI helps acquire high-resolution images of normal pituitary glands and pituitary macroadenomas with relatively few susceptibility artifacts in a clinically feasible scan time. This sequence might be helpful for evaluating the consistency of pituitary macroadenomas.
影响因子：
2.5
作者：
Korn, Natalie;Kurhanewicz, John;Banerjee, Suchandrima;Starobinets, Olga;Saritas, Emine;Noworolski, Susan
通讯作者：
Noworolski, Susan