Epidermal and hepatocyte growth factors stimulate chemotaxis in an intestinal epithelial cell line.
Epidermal and hepatocyte growth factors stimulate chemotaxis in an intestinal epithelial cell line.
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表皮和肝细胞生长因子刺激肠上皮细胞系的趋化性。
DOI：
10.1152/ajpcell.1999.277.6.c1149
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发表时间：
1999
期刊：
影响因子：
--
通讯作者：
Tong,W
中科院分区：
文献类型：
--
作者：
Polk,DB;Tong,W
肠细胞的迁移在正常上皮细胞的发育和维持中是重要的，这一过程可能受到生长因子和细胞因子的调节。虽然一些生长因子受体表达的肠细胞，小的进展已经朝着分配这些配体-受体系统的功能作用。本研究比较了几种生长因子和细胞因子对小鼠小肠上皮细胞系的化学吸引作用。表皮和肝细胞生长因子刺激细胞快速30倍的趋化性，向转化生长因子-β1迁移延迟3倍。尽管刺激增殖，角质形成细胞，成纤维细胞，或胰岛素样生长因子没有刺激定向迁移。趋化性需要酪氨酸激酶和磷脂酰肌醇磷脂酶C的活动，但不是蛋白激酶C或丝裂原活化蛋白激酶活性。这些发现表明，能够调节定向肠上皮细胞迁移的生长因子的库是有限的，并且定向与非定向迁移的信号转导途径存在分歧。
The migration of intestinal cells is important in the development and maintenance of normal epithelium, in a process that may be regulated by growth factors and cytokines. Although a number of growth factor receptors are expressed by intestinal cells, little progress has been made toward assignment of functional roles for these ligand-receptor systems. This study compares several growth factors and cytokines for their chemoattraction of the mouse small intestinal epithelial cell line. Epidermal and hepatocyte growth factors stimulated a rapid 30-fold chemotaxis of cells with delayed threefold migration toward transforming growth factor-β1. Despite stimulating proliferation, keratinocyte, fibroblast, or insulin-like growth factors did not stimulate directed migration. Chemotaxis required tyrosine kinase and phosphatidylinositol phospholipase C activities but not protein kinase C or mitogen-activated protein kinase activity. These findings suggest that the repertoire of growth factors capable of regulating directed intestinal epithelial cell migration is limited and that a divergence exists in the signal transduction pathways for directed vs. nondirected migration.
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影响因子：
29.4
作者：
Egger, B;Procaccino, F;Eysselein, VE
通讯作者：
Eysselein, VE
影响因子：
29.4
作者：
Göke, M;Kanai, M;Podolsky, DK
通讯作者：
Podolsky, DK
影响因子：
29.4
作者：
FEIL, W;LACY, ER;SCHIESSEL, R
通讯作者：
SCHIESSEL, R
影响因子：
5.3
作者：
J. Cárcamo;Frances M B Weis;F. Ventura;R. Wieser;J. Wrana;L. Attisano;J. Massagué
通讯作者：
J. Cárcamo;Frances M B Weis;F. Ventura;R. Wieser;J. Wrana;L. Attisano;J. Massagué
影响因子：
29.4
作者：
DIGNASS, AU;PODOLSKY, DK
通讯作者：
PODOLSKY, DK