Hippocampal sclerosis of aging, a prevalent and high-morbidity brain disease.
Hippocampal sclerosis of aging, a prevalent and high-morbidity brain disease.
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衰老导致的海马硬化是一种普遍且高发病率的脑部疾病。
DOI：
10.1007/s00401-013-1154-1
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发表时间：
2013-08
影响因子：
12.7
通讯作者：
Schmitt FA
中科院分区：
文献类型：
--
作者：
Nelson PT;Smith CD;Abner EL;Wilfred BJ;Wang WX;Neltner JH;Baker M;Fardo DW;Kryscio RJ;Scheff SW;Jicha GA;Jellinger KA;Van Eldik LJ;Schmitt FA
海马衰老硬化症（HS-Aging）是大部分老年痴呆症病例的致病因素。目前 HS-Aging 的定义基于病理学标准：海马结构中的神经元丢失和神经胶质增生，与 AD 型病理不成比例。 HS-Aging 也与 TDP-43 病理密切相关。 HS-Aging 病理学似乎在最年长的老年人中最为普遍：尸检系列表明 5-30% 的九十多岁老人患有 HS-Aging 病理学。在之前的研究中，研究设计的差异导致了报告的疾病患病率的研究间差异。 HS-Aging 病理学的存在与显着的认知障碍相关，临床上经常被误诊为 AD。与海马萎缩相关的其他疾病（包括额颞叶变性和脑血管病变）进一步混淆了生前诊断。描述 HS-Aging 患者神经认知特征的最新进展已开始提供线索，可能有助于识别患有 HS-Aging 病理的活着的个体。尸检后对研究对象进行的结构性脑成像研究显示，与仅患有 AD 病理的人相比，最终患有 HS-Aging 病理的人的海马萎缩程度要严重得多。数据来自于肯塔基大学进行神经认知和神经放射学测量以及神经病理学评估的个体。最后，我们讨论假设导致或改变疾病的因素。我们得出的结论是，已发表的有关 HS-Aging 的文献提供了强有力的证据，证明了一种重要且未被充分认识的衰老脑疾病。不幸的是，目前没有可用的治疗或预防策略。
Hippocampal sclerosis of aging (HS-Aging) is a causative factor in a large proportion of elderly dementia cases. The current definition of HS-Aging rests on pathologic criteria: neuronal loss and gliosis in the hippocampal formation that is out of proportion to AD-type pathology. HS-Aging is also strongly associated with TDP-43 pathology. HS-Aging pathology appears to be most prevalent in the oldest-old: autopsy series indicate that 5–30 % of nonagenarians have HS-Aging pathology. Among prior studies, differences in study design have contributed to the study-to-study variability in reported disease prevalence. The presence of HS-Aging pathology correlates with significant cognitive impairment which is often misdiagnosed as AD clinically. The antemortem diagnosis is further confounded by other diseases linked to hippocampal atrophy including frontotemporal lobar degeneration and cerebrovascular pathologies. Recent advances characterizing the neurocognitive profile of HS-Aging patients have begun to provide clues that may help identify living individuals with HS-Aging pathology. Structural brain imaging studies of research subjects followed to autopsy reveal hippocampal atrophy that is substantially greater in people with eventual HS-Aging pathology, compared to those with AD pathology alone. Data are presented from individuals who were followed with neurocognitive and neuroradiologic measurements, followed by neuropathologic evaluation at the University of Kentucky. Finally, we discuss factors that are hypothesized to cause or modify the disease. We conclude that the published literature on HS-Aging provides strong evidence of an important and under-appreciated brain disease of aging. Unfortunately, there is no therapy or preventive strategy currently available.
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影响因子：
4.2
作者：
Cuenco KT;Friedland R;Baldwin CT;Guo J;Vardarajan B;Lunetta KL;Cupples LA;Green RC;DeCarli C;Farrer LA;MIRAGE Study Group
通讯作者：
MIRAGE Study Group
DOI：
10.1523/jneurosci.1064-09.2009
发表时间：
2009-10-14
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Abdul HM;Sama MA;Furman JL;Mathis DM;Beckett TL;Weidner AM;Patel ES;Baig I;Murphy MP;LeVine H 3rd;Kraner SD;Norris CM
通讯作者：
Norris CM
影响因子：
2
作者：
Armstrong, Richard A.;Cairns, Nigel J.
通讯作者：
Cairns, Nigel J.
影响因子：
--
作者：
Baborie, Atik;Griffiths, Tim D.;Perry, Robert
通讯作者：
Perry, Robert
影响因子：
12.7
作者：
Amador-Ortiz C;Ahmed Z;Zehr C;Dickson DW
通讯作者：
Dickson DW