Barrier mechanisms in the Drosophila blood-brain barrier.
Barrier mechanisms in the Drosophila blood-brain barrier.
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DOI：
10.3389/fnins.2014.00414
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发表时间：
2014
影响因子：
4.3
通讯作者：
Bainton RJ
中科院分区：
文献类型：
--
作者：
Hindle SJ;Bainton RJ
The invertebrate blood-brain barrier (BBB) field is growing at a rapid pace and, in recent years, studies have shown a physiologic and molecular complexity that has begun to rival its vertebrate counterpart. Novel mechanisms of paracellular barrier maintenance through G-protein coupled receptor signaling were the first demonstrations of the complex adaptive mechanisms of barrier physiology. Building upon this work, the integrity of the invertebrate BBB has recently been shown to require coordinated function of all layers of the compound barrier structure, analogous to signaling between the layers of the vertebrate neurovascular unit. These findings strengthen the notion that many BBB mechanisms are conserved between vertebrates and invertebrates, and suggest that novel findings in invertebrate model organisms will have a significant impact on the understanding of vertebrate BBB functions. In this vein, important roles in coordinating localized and systemic signaling to dictate organism development and growth are beginning to show how the BBB can govern whole animal physiologies. This includes novel functions of BBB gap junctions in orchestrating synchronized neuroblast proliferation, and of BBB secreted antagonists of insulin receptor signaling. These advancements and others are pushing the field forward in exciting new directions. In this review, we provide a synopsis of invertebrate BBB anatomy and physiology, with a focus on insights from the past 5 years, and highlight important areas for future study.
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影响因子：
11.8
作者：
Behr, M;Riedel, D;Schuh, R
通讯作者：
Schuh, R
影响因子：
64.5
作者：
Bainton, RJ;Tsai, LTY;Heberlein, U
通讯作者：
Heberlein, U
影响因子：
5.3
作者：
Brankatschk, Marko;Eaton, Suzanne
通讯作者：
Eaton, Suzanne
影响因子：
4.3
作者：
DeSalvo MK;Hindle SJ;Rusan ZM;Orng S;Eddison M;Halliwill K;Bainton RJ
通讯作者：
Bainton RJ
影响因子：
3.7
作者：
Daneman R;Zhou L;Agalliu D;Cahoy JD;Kaushal A;Barres BA
通讯作者：
Barres BA