Metabolic regulation of glioma stem-like cells in the tumor micro-environment.
Metabolic regulation of glioma stem-like cells in the tumor micro-environment.
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DOI：
10.1016/j.canlet.2017.07.014
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发表时间：
2017-11-01
期刊：
影响因子：
9.7
通讯作者：
Yu JS
中科院分区：
文献类型：
--
作者：
Thomas TM;Yu JS
癌症代谢已经成为从一个新的角度重新审视的最有趣的老观点之一。20世纪初，奥托·沃伯格（Otto Warburg）宣称，代谢是一种由许多次要原因引起的疾病的主要原因，鉴于现代对肿瘤进化的真实本质的阐述，这一说法似乎更有先见之明。随着从遗传学角度对肿瘤异质性的复杂性越来越清楚，考虑肿瘤和肿瘤微环境中不可避免的异质性代谢成分是很重要的。高级别胶质瘤仍然是最难治疗的实体肿瘤之一，部分原因是肿瘤的高度血管化性质和肿瘤内维持更耐药的茎样亚群。神经胶质瘤干细胞（GSCs）的维持需要在细胞内和更大的肿瘤微环境中进行信号传导和代谢的特异性改变。胶质瘤内的特定生态位有助于培养具有高致瘤性和高代谢可塑性的干细胞样亚群的存活。了解这些维持途径和生态位内的代谢依赖性可能会突出解决胶质瘤患者肿瘤耐药和复发的潜在途径。
Cancer metabolism has emerged as one of the most interesting old ideas being revisited from a new perspective. In the early 20th century Otto Warburg declared metabolism the prime cause in a disease of many secondary causes, and this statement seems more prescient in view of modern expositions into the true nature of tumor evolution. As the complexity of tumor heterogeneity becomes more clear from a genetic perspective, it is important to consider the inevitably heterogeneous metabolic components of the tumor and the tumor microenvironment. High grade gliomas remain one of the most difficult to treat solid tumors, due in part to the highly vascularized nature of the tumor and the maintenance of more resistant stem-like subpopulations within the tumor. Maintenance of glioma stem cells (GSCs) requires specific alterations within the cells and the greater tumor microenvironment with regards to signaling and metabolism. Specific niches within gliomas help foster the survival of stem-like sub-populations of cells with high tumorigenicity and high metabolic plasticity. Understanding these maintenance pathways and the metabolic dependencies within the niche may highlight potential avenues of addressing tumor resistance and recurrence in glioma patients.
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