A MicroRNA gene is hosted in an intron of a schizophrenia-susceptibility gene.
A MicroRNA gene is hosted in an intron of a schizophrenia-susceptibility gene.
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microRNA基因托管在精神分裂症敏感性基因的内含子中。
DOI：
10.1016/j.schres.2009.01.022
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发表时间：
2009-04
影响因子：
4.5
通讯作者：
Li, Yong
中科院分区：
文献类型：
--
作者：
Zhu, Yanglong;Kalbfleisch, Ted;Brennan, Mark D.;Li, Yong
精神分裂症（SZ）是一种影响约1%成年人的神经精神疾病。许多基因与SZ易感性有关。microrna （miRNA）是一种小RNA分子，通过与mrna的3 '非翻译区相互作用来调节mrna的翻译。对所有人类基因上已知miRNA靶点的鉴定表明，miRNA-346靶点是精神分裂症数据库中列出的SZ易感基因，相对于基因组中其他基因，其频率是预期的两倍。编码该miRNA的基因miR-346位于谷氨酸受体嗜离子δ 1 （GRID1）基因的内含子2中，该基因先前与SZ易感性有关。我们利用Stanley医学研究所Stanley阵列采集的脑RNA样本，采用实时荧光定量PCR检测miR-346和GRID1的表达水平。SZ患者miR-346和GRID1的表达均低于正常对照组（P值分别为0.017和0.086）。然而，在SZ患者中，miR-346和GRID1的表达相关性低于双相患者或正常对照。这项研究暗示了miRNA在SZ中的重要性。
Schizophrenia (SZ) is a neuropsychiatric disorder that affects about 1% of the adult population. Numerous genes have been implicated in SZ susceptibility. MicroRNAs (miRNA) are small RNA molecules that regulate the translation of mRNAs via interactions with their 3’ untranslated regions. Identification of known miRNA targets on all human genes indicated that miRNA-346 targets SZ susceptibility genes listed in the SchizophreniaGene database, twice as frequently than expected relative to other genes in the genome. The gene encoding this miRNA, miR-346, is located in intron 2 of the glutamate receptor ionotropic delta 1 (GRID1) gene, which has been previously implicated in SZ susceptibility. We used quantitative real-time PCR to determine the expression levels of miR-346 and GRID1 using brain RNA samples from the Stanley Array Collection, Stanley Medical Research Institute. Expression of both miR-346 and GRID1 is lower in SZ patients than that in normal controls (P=0.017 and 0.086, respectively). However, the expression of miR-346 and GRID1 is less correlated in SZ patients than in bipolar patients or in normal controls. This study implicates the importance of a miRNA in SZ.
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