Sleep, clocks, and synaptic plasticity.
Sleep, clocks, and synaptic plasticity.
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DOI：
10.1016/j.tins.2014.06.005
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发表时间：
2014-09
影响因子：
15.9
通讯作者：
Cantera R
中科院分区：
文献类型：
--
作者：
Frank MG;Cantera R
Sleep is widely believed to play an essential role in synaptic plasticity. However, the precise mechanisms governing this presumptive function are largely unknown. There is also evidence for independent circadian oscillations in synaptic strength and morphology. Therefore, synaptic changes observed after sleep reflect interactions between state-dependent (e.g. wake vs. sleep) and state-independent (circadian) processes. In this article we review how sleep and biological clocks influence synaptic plasticity. We discuss these findings in the context of current plasticity-based theories of sleep function and propose a new model that integrates circadian and brain state influences on synaptic plasticity.
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DOI：
10.1126/science.1202839
发表时间：
2011-06-24
期刊：
Science (New York, N.Y.)
影响因子：
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