Duration of untreated psychosis and social function: 1-year follow-up study of first-episode schizophrenia.
Duration of untreated psychosis and social function: 1-year follow-up study of first-episode schizophrenia.
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DOI：
10.1192/bjp.bp.108.049718
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发表时间：
2008-09
期刊：
影响因子：
--
通讯作者：
Joyce EM
中科院分区：
文献类型：
--
作者：
Barnes TR;Leeson VC;Mutsatsa SH;Watt HC;Hutton SB;Joyce EM
在首发精神分裂症中，精神病未治疗时间（DUP）越长，预后越差。目的探讨DUP与预后之间的关系是直接因果关系，还是同一时间点症状和/或认知功能与社会功能之间的关联结果。方法对98例首发精神分裂症患者在就诊时及1年后进行症状、社会功能及认知功能评定。结果在就诊时短DUP和长DUP的参与者之间没有显著的临床差异。线性回归分析显示，较长的DUP显着预测更严重的阳性和阴性症状和较差的社会功能，在1年，独立的分数在介绍。 路径分析显示DUP与社会功能、核心阴性症状和阳性症状之间存在独立的直接关系。DUP与认知功能无显著相关性。结论长期DUP预示着社会功能不佳，与症状无关。这些发现强调了在调查DUP的影响时，考虑到阴性症状和社会功能措施之间的现象学重叠的重要性。
Background In first-episode schizophrenia, longer duration of untreated psychosis (DUP) predicts poorer outcomes. Aims To address whether the relationship between DUP and outcome is a direct causal one or the result of association between symptoms and/or cognitive functioning and social functioning at the same time point. Method Symptoms, social function and cognitive function were assessed in 98 patients with first-episode schizphrenia at presentation and 1 year later. Results There was no significant clinical difference between participants with short and long DUP at presentation. Linear regression analyses revealed that longer DUP significantly predicted more severe positive and negative symptoms and poorer social function at 1 year, independent of scores at presentation. Path analyses revealed independent direct relationships between DUP and social function, core negative symptoms and positive symptoms. There was no significant association between DUP and cognition. Conclusions Longer DUP predicts poor social function independently of symptoms. The findings underline the importance of taking account of the phenomenological overlap between measures of negative symptoms and social function when investigating the effects of DUP.
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