Clinical Significance of Daytime Plasma Orexin-A-Like Immunoreactivity Concentrations in Patients with Obstructive Sleep Apnea Hypopnea Syndrome
Clinical Significance of Daytime Plasma Orexin-A-Like Immunoreactivity Concentrations in Patients with Obstructive Sleep Apnea Hypopnea Syndrome
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阻塞性睡眠呼吸暂停低通气综合征患者日间血浆食欲素 A 样免疫反应性浓度的临床意义
DOI：
10.1159/000079643
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发表时间：
2004
期刊：
影响因子：
3.7
通讯作者：
Kazuhiro Takahashi
中科院分区：
文献类型：
--
作者：
S. Sakurai;Tsuguo Nishijima;Susumu Takahashi;K. Yamauchi;Z. Arihara;Kazuhiro Takahashi
背景资料：多导睡眠图（PSG）测试是非常复杂和耗时的，尽管它们在诊断阻塞性睡眠呼吸暂停低通气综合征（OSAHS）患者的临床益处。血浆标志物将是理想的选择疑似OSAHS的患者进行进一步的PSG研究。我们最近报道了OSAHS患者清晨醒来后立即收集的血浆中食欲素A浓度显著低于对照组。目的：我们进行了本研究，以评估在白天获得的血浆食欲素-A浓度的测量作为诊断预测筛选OSAHS患者的临床实用性。方法：对19例疑似睡眠呼吸障碍的男性患者进行日间血液采样。采用放射免疫法测定PSG前血浆食欲素A浓度。结果：19例受试者均进行了PSG检查。PSG显示14名受试者有OSAHS，5名受试者没有。OSAHS患者血浆食欲素A浓度（4.9 ± 0.8 pmol/l，平均值±标准误，n = 14）显著低于对照组（12.3 ± 1.9 pmol/l，n = 5）（p = 0.0004）。结论：这些发现表明，即使在白天获得的血浆食欲素-A浓度可能是一个有用的血浆标志物筛查OSAHS。
Background: Polysomnography (PSG) tests are very complicated and time consuming, despite their clinical benefits in the diagnosis of patients with obstructive sleep apnea hypopnea syndrome (OSAHS). A plasma marker would be desirable to select patients suspected of OSAHS for further PSG studies. We have recently reported that orexin-A concentrations in plasma collected immediately after waking early in the morning were significantly lower in patients with OSAHS than in controls. Objectives: We conducted the present study to assess the clinical usefulness of the measurement of orexin-A concentrations in plasma obtained in the daytime as a diagnostic predictor to screen patients with OSAHS. Methods: Blood samples were collected in the daytime from 19 male patients with suspected sleep-disordered breathing. Plasma orexin-A concentrations were measured by radioimmunoassay before performing PSG. Results: PSG was conducted in all 19 subjects. PSG showed that 14 subjects had OSAHS and 5 subjects did not. Plasma orexin-A concentrations were significantly lower in patients with OSAHS (4.9 ± 0.8 pmol/l, mean ± SE, n = 14) than in control subjects (12.3 ± 1.9 pmol/l, n = 5) (p = 0.0004). Conclusions: These findings suggest that the orexin-A concentration in plasma obtained even in the daytime may be a useful plasma marker for screening OSAHS.
DOI：
10.1073/pnas.95.1.322
发表时间：
1998-01-06
影响因子：
11.1
作者：
De Lecea, L;Kilduff, TS;Sutcliffe, JG
通讯作者：
Sutcliffe, JG