Microtubule-associated protein Mdp3 promotes breast cancer growth and metastasis.
Microtubule-associated protein Mdp3 promotes breast cancer growth and metastasis.
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微管相关蛋白 Mdp3 促进乳腺癌生长和转移。
作者：
Tala;Xie S;Sun X;Sun X;Ran J;Zhang L;Li D;Liu M;Bao G;Zhou J
乳腺癌是世界范围内女性中最常见的癌症，死亡率高，并且非常需要鉴定这种疾病的新生物标志物和靶标。在这里，我们提出的证据表明，微管相关蛋白（MAP）7域含有蛋白3（Mdp 3）是高度表达的临床样本和乳腺癌细胞系。Mdp 3的表达与乳腺癌恶性程度的临床病理参数相关。此外，Mdp 3在体外促进乳腺癌细胞增殖和运动，并刺激小鼠乳腺癌的生长和转移。机制研究表明，γ-微管蛋白与Mdp 3相互作用并将其募集到中心体，并且Mdp 3的中心体定位是其促进乳腺癌细胞增殖和运动的活性所必需的。这些发现表明Mdp 3在乳腺癌的生长和转移中起关键作用，并可能对这种疾病的管理具有重要意义。
Breast cancer is the most prevalent cancer in women worldwide with a high mortality rate, and the identification of new biomarkers and targets for this disease is greatly needed. Here we present evidence that microtubule-associated protein (MAP) 7 domain-containing protein 3 (Mdp3) is highly expressed in clinical samples and cell lines of breast cancer. The expression of Mdp3 correlates with clinicopathological parameters indicating breast cancer malignancy. In addition, Mdp3 promotes breast cancer cell proliferation and motility in vitro and stimulates breast cancer growth and metastasis in mice. Mechanistic studies reveal that γ-tubulin interacts with and recruits Mdp3 to the centrosome and that the centrosomal localization of Mdp3 is required for its activity to promote breast cancer cell proliferation and motility. These findings suggest a critical role for Mdp3 in the growth and metastasis of breast cancer and may have important implications for the management of this disease.
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