Clinical characteristics of different histologic types of breast cancer.
Clinical characteristics of different histologic types of breast cancer.
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DOI：
10.1038/sj.bjc.6602787
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发表时间：
2005-10-31
影响因子：
8.8
通讯作者：
Daling, JR
中科院分区：
文献类型：
--
作者：
Li, CI;Uribe, DJ;Daling, JR
乳腺癌是一种异质性疾病，尽管对其一些罕见形式（包括某些组织学类型）知之甚少。使用监测，流行病学，和最终结果计划的135 157例浸润性乳腺癌病例诊断从1992年至2001年，9种组织学类型的乳腺癌和各种肿瘤特征之间的关系进行了评估。在诊断时年龄在50-89岁的女性中，与导管癌病例相比，小叶癌和导管/小叶癌病例更有可能被诊断为III/IV期、直径<5.0 cm和淋巴结阳性肿瘤。粘液癌、粉刺癌、管状癌和髓样癌不太可能出现在晚期。小叶、导管/小叶、粘液性、管状和乳头状癌的可能性较小，粉刺、髓样和炎性癌更可能是雌激素受体（ER）阴性/孕激素受体（PR）阴性和高级别（值得注意的是，68.2%的髓样癌是ER−/PR−，而导管癌是19.3%）。一般来说，在30-49岁诊断的妇女中观察到类似的差异。炎性癌与更具侵袭性的肿瘤表型相关，而粘液性、管状和乳头状肿瘤与侵袭性较低的表型相关。本文研究的乳腺癌组织学类型在临床表现上差异很大，其激素受体谱和等级的差异表明它们可能有不同的病因。
Breast cancer is a heterogeneous disease, though little is known about some of its rarer forms, including certain histologic types. Using Surveillance, Epidemiology, and End Results Program data on 135 157 invasive breast cancer cases diagnosed from 1992 to 2001, relationships between nine histologic types of breast cancer and various tumour characteristics were assessed. Among women aged 50–89 years at diagnosis, lobular and ductal/lobular carcinoma cases were more likely to be diagnosed with stage III/IV, ⩾5.0 cm, and node-positive tumours compared to ductal carcinoma cases. Mucinous, comedo, tubular, and medullary carcinomas were less likely to present at an advanced stage. Lobular, ductal/lobular, mucinous, tubular, and papillary carcinomas were less likely, and comedo, medullary, and inflammatory carcinomas were more likely to be oestrogen receptor (ER) negative/progesterone receptor (PR) negative and high grade (notably, 68.2% of medullary carcinomas were ER−/PR− vs 19.3% of ductal carcinomas). In general, similar differences were observed among women diagnosed at age 30–49 years. Inflammatory carcinomas are associated with more aggressive tumour phenotypes, and mucinous, tubular, and papillary tumours are associated with less aggressive phenotypes. The histologic types of breast cancer studied here differ greatly in their clinical presentations, and the differences in their hormone receptor profiles and grades point to their likely different aetiologies.
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影响因子：
120.7
作者：
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通讯作者：
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