Gankyrin is frequently overexpressed in cervical high grade disease and is associated with cervical carcinogenesis and metastasis.
Gankyrin is frequently overexpressed in cervical high grade disease and is associated with cervical carcinogenesis and metastasis.
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Gankyrin 在宫颈重度疾病中经常过度表达，并与宫颈癌发生和转移相关。
DOI：
10.1371/journal.pone.0095043
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Wu S
中科院分区：
文献类型：
--
作者：
Liu Y;Zhang J;Qian W;Dong Y;Yang Y;Liu Z;Feng Y;Ma D;Zhang Z;Wu S
我们以前的研究表明Gankyrin的表达与子宫内膜癌的恶性表型相关。在这里，我们研究了Gankyrin在宫颈疾病中的可能作用。Gankyrin在高级别宫颈上皮内瘤变和宫颈癌中的表达水平高于良性宫颈组织和低级别宫颈上皮内瘤变。在癌旁组织中，当Gankyrin核表达阳性时，无淋巴结转移，而当Gankyrin核表达阴性时，淋巴结转移率为30%（6/20）。体外转染Gankyrin后，宫颈癌细胞Vimentin、β-catenin和Twist 2表达明显上调，E-cadherin表达明显下调。我们的研究结果表明，Gankyrin可能在宫颈癌的发生和转移的功能。
Our previous studies have showed that Gankyrin expression is correlated with a malignant phenotype in endometrial carcinoma. Here, we investigated the possible role of Gankyrin in cervical disease. The increasing protein level of Gankyrin was observed in high-grade cervical intraepithelial neoplasia and carcinoma compared with benign cervical tissues and low-grade cervical intraepithelial neoplasia. In para-carcinoma tissues, it was found interestingly that there was no lymph node metastasis when nuclei Gankyrin was positively expressed, but lymph node metastasis rate was 30% (6/20) when nuclei Gankyrin was negatively expressed. In vitro, the transfection of Gankyrin resulted in markedly up-regulating of Vimentin, β-catenin and Twist2, as well as down-regulating of E-cadherin in cervical carcinoma cells. Our results suggested that Gankyrin may be functional in cervical carcinogenesis and metastasis.
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影响因子：
3.7
作者：
Mao Y;Xu J;Li Z;Zhang N;Yin H;Liu Z
通讯作者：
Liu Z
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影响因子：
9.7
作者：
Meng, Yun;He, Lijie;Fan, Daiming
通讯作者：
Fan, Daiming
影响因子：
3.6
作者：
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通讯作者：
Park, Tae Jun
影响因子：
3.8
作者：
Yan M;Xu Q;Zhang P;Zhou XJ;Zhang ZY;Chen WT
通讯作者：
Chen WT
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DOI：
10.1097/igc.0b013e318292da82
发表时间：
2013-06-01
影响因子：
4.8
作者：
Wu, Zhao;Peng, Xue;Hu, Lina
通讯作者：
Hu, Lina