Lymphocyte compartments in human spleen. An immunohistologic study in normal spleens and uninvolved spleens in Hodgkin's disease.

Lymphocyte compartments in human spleen. An immunohistologic study in normal spleens and uninvolved spleens in Hodgkin's disease.
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人脾脏中的淋巴细胞区室。

DOI:
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发表时间:
1985
影响因子:
6
通讯作者:
S. Poppema
S. Poppema
中科院分区:
医学2区
文献类型:
--
作者:
W. Timens;S. Poppema

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采用一组针对T和B淋巴细胞抗原的单克隆抗体,分析了13例正常人脾脏(3例新生儿)和17例霍奇金病患者脾脏中几种淋巴细胞亚群的存在和定位。白色牙髓的细胞分布与其他次级淋巴器官的发现一致,除了存在一个边缘区,一个位于白色和红色牙髓边界的独特的隔室。边缘区细胞的表型表明,边缘区可能包含非再循环B细胞和再循环B细胞,而T细胞(辅助性T细胞)也有代表。因此,认为边缘带细胞是非再循环IgM+、IgD-细胞的观点似乎过于简单化了。何杰金氏病患者脾脏与非何杰金氏病患者脾脏无明显差异。
A panel of monoclonal antibodies directed against T and B lymphocyte antigens was used to analyze the presence and localization of several lymphocyte subsets in 13 normal human spleens (3 of newborns) and 17 uninvolved spleens of patients with Hodgkin's disease. The distribution of cells in the white pulp corresponded with findings in other secondary lymphoid organs, except for the presence of a marginal zone, a unique compartment localized at the border of white and red pulp. The phenotype of the marginal zone cells indicates that it is likely that the marginal zone contains nonrecirculating as well as recirculating B cells, while T cells (of the T helper type) are also represented. Therefore, the notion that marginal zone cells are nonrecirculating IgM+, IgD- cells, appears to be an oversimplification. No clear differences were observed between spleens of patients with and without Hodgkin's disease.
DOI: 10.4049/jimmunol.125.4.1678
发表时间: 1980-10
影响因子: 4.4
作者:
P. Stashenko;L. Nadler;R. Hardy;S. Schlossman
通讯作者: P. Stashenko;L. Nadler;R. Hardy;S. Schlossman
不同于 B1 的人类 B 细胞特异性抗原 (B2) 的表征。
DOI: --
发表时间: 1981
期刊: Journal of immunology (Baltimore, Md. : 1950)
影响因子: --
作者:
Nadler,LM;Stashenko,P;Hardy,R;vanAgthoven,A;Terhorst,C;Schlossman,SF
通讯作者: Schlossman,SF
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DOI: --
发表时间: 1983
期刊: The American journal of pathology
影响因子: --
作者:
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通讯作者: Bhan,AK
与人 B 淋巴细胞谱系细胞发生反应的单克隆抗体 (BA-1)。
DOI: --
发表时间: 1981
期刊: Journal of immunology (Baltimore, Md. : 1950)
影响因子: --
作者:
Abramson,CS;Kersey,JH;LeBien,TW
通讯作者: LeBien,TW