Lung mast cell density defines a subpopulation of patients with idiopathic pulmonary fibrosis.
Lung mast cell density defines a subpopulation of patients with idiopathic pulmonary fibrosis.
复制标题
DOI：
10.1111/j.1365-2559.2012.04197.x
复制
发表时间：
2012-07
期刊：
影响因子：
6.4
通讯作者：
Wolters PJ
中科院分区：
文献类型：
--
作者：
Cha SI;Chang CS;Kim EK;Lee JW;Matthay MA;Golden JA;Elicker BM;Jones K;Collard HR;Wolters PJ
尽管肥大细胞在肺纤维化患者的肺中存在，但其与肺纤维化发病机制的关系仍不明确。本研究旨在探讨肥大细胞与肺纤维化疾病的关系。对特发性肺纤维化（IPF）、慢性过敏性肺炎（HP）、系统性硬化症（SSc）相关间质性肺病（ILD）患者和正常人的肺组织进行糜酶免疫染色，并定量肥大细胞密度。通过嗜酸性粒细胞过氧化物酶免疫染色定量嗜酸性粒细胞。肺功能的变化与肥大细胞密度相关。从IPF患者获得的肺组织中的糜酶免疫反应性肥大细胞密度高于HP、SSc相关ILD或正常肺患者。IPF肺组织嗜酸性粒细胞密度高于正常肺组织。IPF肺组织中肥大细胞密度与嗜酸性粒细胞密度之间无相关性。肥大细胞密度高的IPF患者的用力肺活量（FVC）下降速度慢于肥大细胞密度低的IPF患者。IPF肺中的肥大细胞密度高于其他纤维化肺病和正常肺。IPF中肥大细胞密度增加可能预示疾病进展较慢。
The relationship of mast cells to the pathogenesis of lung fibrosis remains undefined despite recognition of their presence in the lungs of patients with pulmonary fibrosis. This study was performed to characterize the relationship of mast cells to fibrotic lung diseases. Lung tissues from patients with idiopathic pulmonary fibrosis (IPF), chronic hypersensitivity pneumonitis (HP), systemic sclerosis (SSc)-related interstitial lung disease (ILD) and normal individuals were subjected to chymase immunostaining and the mast cell density quantified. Eosinophils were quantified by immunostaining for eosinophil peroxidase. Changes in lung function were correlated with mast cell density. Lung tissue obtained from IPF patients had a higher density of chymase-immunoreactive mast cells than that from patients with HP, SSc-related ILD or normal lungs. IPF lung tissue had a higher density of eosinophils than normal lung. There was no correlation between mast cell density and eosinophil density in IPF lung. IPF patients with high mast cell density had a slower rate of decline in forced vital capacity (FVC) than IPF patients with low mast cell density. Mast cell density in IPF lungs is higher than in other fibrotic lung diseases and normal lungs. Increased mast cell density in IPF may predict slower disease progression.
登录
查看更多内容
影响因子：
4.9
作者：
Jin, D;Takai, S;Miyazaki, M
通讯作者：
Miyazaki, M
影响因子：
6.4
作者：
Collard, H. R.;Cool, C. D.;Brown, K. K.
通讯作者：
Brown, K. K.
影响因子：
32.4
作者：
Barrett, Nora A.;Austen, K. Frank
通讯作者：
Austen, K. Frank
影响因子：
9.6
作者：
Enomoto, Noriyuki;Suda, Takafumi;Chida, Kingo
通讯作者：
Chida, Kingo
DOI：
10.1164/rccm.200211-1311oc
发表时间：
2003-09-01
影响因子：
24.7
作者：
Collard, HR;King, TE;Brown, KK
通讯作者：
Brown, KK