Paternal and maternal genetic and environmental contributions to cerebrospinal fluid monoamine metabolites in rhesus monkeys (Macaca mulatta).
Paternal and maternal genetic and environmental contributions to cerebrospinal fluid monoamine metabolites in rhesus monkeys (Macaca mulatta).
复制标题
父本和母本遗传和环境对恒河猴（Macaca mulatta）脑脊液单胺代谢物的贡献。
DOI：
10.1001/archpsyc.1993.01820200025003
复制
发表时间：
1993
影响因子：
--
通讯作者：
Markku Linnoila
中科院分区：
文献类型：
--
作者：
J. Higley;William W. Thompson;M. Champoux;David Goldman;Mariken F. Hasert;Gary W. Kraemer;James M. Scanlan;S. Suomi;Markku Linnoila
背景
为了研究遗传和环境对脑脊液（CSF）单胺浓度的影响，将55只年轻的恒河猴（Macaca mulatta）与10只父亲分开饲养，进行父系半同胞分析。
方法
为了研究母亲的遗传贡献，23名婴儿与母亲一起抚养，23名婴儿在出生时从母亲身边带走并与无关的哺乳期母猴一起抚养，24名婴儿在出生时从母亲身边带走并与年龄匹配的同龄人一起抚养。当猴子达到6个月大时，在一系列社会分离之前和期间通过脑池穿刺获得CSF样品。
结果
当根据生物学父亲对结果进行统计学合并时，使用方差分析的比较表明CSF 5-羟基吲哚乙酸（5-HIAA）和高香草酸（HVA）浓度均显示出显著的遗传（h2）效应（h2 > 0.5）对于儿子和女儿，而3-甲氧基-4-羟基苯乙二醇（MHPG）仅对儿子表现出接近显著的父系遗传效应（h2 > 0.5）。此外，母源遗传对幼猴脑脊液MHPG和5-HIAA水平也有显著影响（h2 > 0.5）。结构方程分析表明，母亲的遗传贡献没有母亲的环境贡献CSF 5-HIAA浓度，另一方面，有母亲的遗传和环境的贡献MHPG。
结论
这些研究结果表明，单胺神经递质的营业额的变化的显着部分是由遗传机制决定的。
BACKGROUND
To study genetic and environmental contributions to cerebrospinal fluid (CSF) monoamine concentrations, 55 young rhesus monkeys (Macaca mulatta) were reared apart from their 10 fathers to perform a paternal half-sibling analysis.
METHODS
To study maternal genetic contributions, 23 infants were reared with their mothers, 23 infants were removed from their mothers at birth and fostered to unrelated lactating female monkeys, and 24 infants were removed from their mothers at birth and reared with age-matched peers. When the monkeys reached age 6 months, CSF samples were obtained via cisternal puncture prior to and during a series of social separations.
RESULTS
When the results were statistically pooled according to the biological father, comparisons using analysis of variance indicated that both CSF 5-hydroxyindoleacetic acid (5-HIAA) and homovanillic acid (HVA) concentrations showed significant heritable (h2) effects (h2 > 0.5) for both sons and daughters, whereas 3-methoxy-4-hydroxyphenylglycol (MHPG) showed a nearly significant paternal genetic effect only for sons (h2 > 0.5). In addition, there were substantial maternal genetic influences on the young monkeys' CSF MHPG and 5-HIAA (h2 > 0.5) levels. Structural equation analyses indicated a maternal genetic contribution without a maternal environmental contribution to CSF 5-HIAA concentration; on the other hand, there was both a maternal genetic and environmental contribution to MHPG.
CONCLUSIONS
These findings suggest that a significant portion of the variance in the turnover of the monoamine neurotransmitters is determined by genetic mechanisms.
影响因子：
56.9
作者：
CLONINGER, CR
通讯作者：
CLONINGER, CR
混合纵向和横截面数据的结构建模。
影响因子：
1.8
作者：
McArdle,JJ;Hamagami,F;Elias,MF;Robbins,MA
通讯作者：
Robbins,MA