Oxygen Free‐Radical Reduction of Brain Capillary Rubidium Uptake
Oxygen Free‐Radical Reduction of Brain Capillary Rubidium Uptake
复制标题
氧自由基减少脑毛细血管铷摄取
作者：
W. Lo;A. Betz
摘要： 自由基在以脑水肿为突出特征的脑缺血损伤中发挥着重要作用。为了确定自由基是否会改变离子和水穿过血脑屏障的运动，我们检查了它们对脑毛细血管运输的影响。分离大鼠脑毛细血管，与产生自由基的系统一起孵育，并研究各种毛细血管运输系统。铷吸收减少了 74%，而铷流出、葡萄糖转运和毛细管水空间没有变化。添加自由基清除剂后的结果表明过氧化氢或相关自由基是有毒物质。这些数据表明自由基会损害毛细血管内皮细胞机制，从而帮助维持大脑中电解质和水的稳态。
Abstract: Free radicals are proposed to play a role in the injury following cerebral ischemia in which cerebral edema is a prominent feature. To determine whether free radicals might alter the movement of ions and water across the blood‐brain barrier, we examined their effect on brain capillary transport. Rat brain capillaries were isolated, incubated with a system that generates free radicals, and various capillary transport systems were studied. Rubidium uptake was reduced 74% whereas rubidium efflux, glucose transport, and capillary water space were unchanged. The results following the addition of radical scavengers indicated that hydrogen peroxide or a related free radical was the toxic species. These data suggest that free radicals can impair capillary endothelial cell mechanisms that help maintain homeostasis of electrolytes and water in brain.
类固醇抑制大鼠脑中分离的毛细血管对钾的吸收。
影响因子：
5.8
作者：
Chaplin,ER;Free,RG;Goldstein,GW
通讯作者：
Goldstein,GW