New alcohol markers--how useful are they in population studies: the Svalbard Study 1988-89.
New alcohol markers--how useful are they in population studies: the Svalbard Study 1988-89.
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新的酒精标记——它们在人口研究中有何用处：斯瓦尔巴群岛研究 1988-89。
DOI：
10.1111/j.1530-0277.1992.tb00641.x
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
Olav Helge Førde
中科院分区：
文献类型：
--
作者：
O. Nilssen;Nils;Georg Høyer;T. Brenn;H. Schirmer;Olav Helge Førde
在选定的人群中经常高消费酒精，具有高精度，确定了两个新的酒精标志物：碳水化合物缺乏转铁蛋白和线粒体天冬氨酸转氨酶。为了测试这些标志物在挪威人口，γ-谷氨酰转移酶（GGT），碳水化合物缺乏转铁蛋白（CDT），和线粒体天冬氨酸转氨酶（mAST）进行了测量，在挪威人口，310名男性和171名女性，年龄在18至60岁，生活在斯瓦尔巴群岛。使用自我报告的酒精摄入量作为金标准，根据酒精摄入量和测试的不同截止点估计灵敏度，特异性，阳性预测值和似然比。与早期研究相比，敏感性一般较低。在90%或更高的特异性下，任何测试的灵敏度都不超过26%。而CDT显示其最好的歧视权力在较低的酒精摄入量，GGT歧视最好的在较高的水平。CDT和GGT的并行和串行分析表明，测试之间的条件独立性，以及在较高和较低水平的酒精消费。mAST被判定为不适用于人群研究。
Regular high consumption of alcohol in selected populations have, with high precision, been identified by two new alcohol markers; carbohydrate-deficient transferrin and mitochondrial aspartate aminotransferase. To test these markers in an unselected population, gamma-glutamyltransferase (GGT), carbohydrate-deficient transferrin (CDT), and mitochondrial aspartate aminotransferase (mAST) were measured in the Norwegian population, 310 males and 171 females, aged 18 to 60 years, living at Svalbard. Using self-reported alcohol intake as gold standard, sensitivity, specificity, positive predictive value, and likelihood-ratio were estimated according to different cutoff-points for alcohol intake and for the tests. In contrast to earlier studies, the sensitivity was in general low. With a specificity of 90% or higher, the sensitivity did not exceed 26% for any of the tests. Whereas CDT showed its best discriminatory power at lower intake of alcohol, GGT discriminated best at higher levels. Parallel and serial analysis of CDT and GGT indicated a conditional independence between the tests, as well as at higher and at lower levels of alcohol consumption. mAST was judged as not suitable in population studies.
戒酒后缺乏碳水化合物的转铁蛋白水平发生变化。
DOI：
10.1111/j.1530-0277.1988.tb00239.x
发表时间：
1988
期刊：
Alcoholism, clinical and experimental research
影响因子：
--
作者：
Behrens,UJ;Worner,TM;Lieber,CS
通讯作者：
Lieber,CS