The role of mitochondria in reactive oxygen species metabolism and signaling.
The role of mitochondria in reactive oxygen species metabolism and signaling.
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DOI：
10.1196/annals.1427.015
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发表时间：
2008-12
影响因子：
5.2
通讯作者：
Starkov AA
中科院分区：
文献类型：
--
作者：
Starkov AA
氧化应激被认为是“正常”衰老和严重病理学的主要病因，具有严重的公共卫生影响。已知几种细胞来源，包括线粒体，产生大量的活性氧（ROS），其可能有助于细胞内氧化应激。线粒体拥有至少10个已知的能够产生ROS的位点，但它们也具有复杂的多层ROS防御系统，这是研究得少得多。本文综述了线粒体活性氧代谢的主要成分以及在线粒体水平上调控活性氧产生和清除的因素。一个完整的系统的方法是适用于分析线粒体活性氧代谢，这是“解剖”成活性氧的产生，活性氧的排放，和活性氧清除。几个线粒体位点的体外ROS生产能力进行了比较，在代谢的背景下，线粒体的ROS依赖的细胞内信号转导的作用进行了讨论。
Oxidative stress is considered a major contributor to the etiology of both “normal” senescence and severe pathologies with serious public health implications. Several cellular sources, including mitochondria, are known to produce significant amounts of reactive oxygen species (ROS) that may contribute to intracellular oxidative stress. Mitochondria possess at least 10 known sites that are capable of generating ROS, but they also feature a sophisticated multilayered ROS defense system that is much less studied. This review summarizes the current knowledge about major components involved in mitochondrial ROS metabolism and factors that regulate ROS generation and removal at the level of mitochondria. An integrative systemic approach is applied to analysis of mitochondrial ROS metabolism, which is “dissected” into ROS generation, ROS emission, and ROS scavenging. The in vitro ROS-producing capacity of several mitochondrial sites is compared in the metabolic context and the role of mitochondria in ROS-dependent intracellular signaling is discussed.
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DOI：
10.1006/bbrc.2001.4578
发表时间：
2001-03-23
影响因子：
3.1
作者：
Burkitt, MJ;Wardman, P
通讯作者：
Wardman, P
影响因子：
4.2
作者：
BENZI, G;PASTORIS, O;DOSSENA, M
通讯作者：
DOSSENA, M
影响因子：
4.7
作者：
Chinopoulos, C;Tretter, L;Adam-Vizi, V
通讯作者：
Adam-Vizi, V
影响因子：
4.1
作者：
BOVERIS, A;CHANCE, B
通讯作者：
CHANCE, B
影响因子：
5.9
作者：
DEGROOT, H;SIES, H
通讯作者：
SIES, H