Multiple Anesthesia/Surgery Cannot Impair Reference Memory in Adult Mice
Multiple Anesthesia/Surgery Cannot Impair Reference Memory in Adult Mice
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多次麻醉/手术不会损害成年小鼠的参考记忆
DOI：
10.1155/2020/3736912
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发表时间：
2020-03
影响因子：
4.6
通讯作者：
Su Diansan
中科院分区：
文献类型：
--
作者：
Zhou Xiaoxin;Lu Jian;Wu Tong;Jiang Xuliang;Tian Weitian;Dai Wanbing;Qi Siyi;Chen Xuemei;Zhang Jiaqiang;Su Diansan
术后认知功能障碍会增加围手术期患者的死亡率和发病率。大量研究表明，在神经发育阶段进行多次手术/麻醉会影响认知功能，而单次麻醉……（原文此处“a single anesthes”表述不完整，推测可能是“a single anesthesia”，即“单次麻醉” ）
Postoperative cognitive dysfunction increases mortality and morbidity in perioperative patients. Numerous studies have demonstrated that multiple surgery/anesthesia during the neurodevelopmental period affects cognitive function, whereas a single anesthesia/surgery rarely causes cognitive dysfunction in adults. However, whether adults who undergo multiple anesthesia/surgery over a short period will experience cognitive dysfunction remains unclear. In this study, central nervous system inflammation and changes in cholinergic markers were investigated in adult mice subjected to multiple laparotomy procedures over a short period of time. The results showed that despite the increased expression of IL-6 and TNF-α in the hippocampus after multiple operations and the activation of microglia, multiple anesthesia/surgery did not cause a decline in cognitive function in adult mice. There were no changes in the cholinergic markers after multiple anesthesia/surgery.
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影响因子：
9.8
作者：
Hanning, CD
通讯作者：
Hanning, CD
DOI：
10.1016/j.bbi.2015.07.008
发表时间：
2015-11
期刊：
Brain, Behavior, and Immunity
影响因子：
--
作者：
Jin A Shin;Sae Im Jeong;Minsuk Kim;J. Yoon;Hee-Sun Kim;E. Park
通讯作者：
Jin A Shin;Sae Im Jeong;Minsuk Kim;J. Yoon;Hee-Sun Kim;E. Park
手术引起的神经炎症不会损害年轻成年小鼠的参考记忆
影响因子：
4.6
作者：
Zhao Y;Huang L;Xu H;Wu G;Zhu M;Tian J;Wang H;Wang X;Yu W;Yang L;Su D
通讯作者：
Su D
影响因子：
3.3
作者：
Yon, JH;Daniel-Johnson, J;Jevtovic-Todorovic, V
通讯作者：
Jevtovic-Todorovic, V
影响因子：
1.3
作者：
Valerie J. Page;Fiona C. Oglesby;Richard A. Armstrong
通讯作者：
Valerie J. Page;Fiona C. Oglesby;Richard A. Armstrong