No effect of insertion/ deletion polymorphism at the ACE locus on normal blood pressure level or variability
No effect of insertion/ deletion polymorphism at the ACE locus on normal blood pressure level or variability
复制标题
ACE 位点插入/缺失多态性对正常血压水平或变异性没有影响
作者：
K. Berge;K. Berg
血管紧张素 I 转换酶 (ACE) 将血管紧张素 I 裂解为血管紧张素 II，血管紧张素 II 是肾素-血管紧张素系统 (RAS) 的活性成分。我们研究了 DNA ACE 基因座的插入/缺失多态性。在由 140、90 和 136 个无关个体组成的三个不同系列中，我们没有发现该插入/缺失 (I/D) 多态性的基因型与收缩压或舒张压水平之间存在关联的证据。在分别由 130 对和 88 对同卵 (MZ) 双胞胎组成的两个系列中，收缩压或舒张压的配对内变异的基因型之间没有差异。因此，在这一系列健康人中，没有观察到这种插入/缺失多态性的“水平基因”和“变异基因”效应。
Angiotensin I‐converting enzyme (ACE) cleaves angiotensin I to angiotensin II, which is the active component in the renin‐angiotensin system (RAS). We have studied an insertion/deletion polymorphism in DNA at the ACE locus. In three different series comprising 140, 90 and 136 unrelated individuals we found no evidence of association between genotypes in this insertion/deletion (I/D) polymorphism and level of systolic or diastolic blood pressure. In two series of 130 and 88 monozygotic (MZ) twin pairs, respectively, there was no difference between genotypes in within‐pair variation in systolic or diastolic blood pressure. Thus, in these series of healthy people, neither “level gene” nor “variability gene” effects of this insertion/deletion polymorphism were observed.
有证据表明，具有性别和年龄依赖性效应的单个基因会影响基于人群的样本中收缩压的测定。
影响因子：
9.8
作者：
Pérusse,L;Moll,PP;Sing,CF
通讯作者：
Sing,CF
影响因子：
56.9
作者：
RAPP, JP;WANG, SM;DENE, H
通讯作者：
DENE, H