Exercise - induced changes in cerebrospinal fluid miRNAs in Gulf War Illness, Chronic Fatigue Syndrome and sedentary control subjects.
Exercise - induced changes in cerebrospinal fluid miRNAs in Gulf War Illness, Chronic Fatigue Syndrome and sedentary control subjects.
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DOI：
10.1038/s41598-017-15383-9
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发表时间：
2017-11-10
影响因子：
4.6
通讯作者：
Shivapurkar N
中科院分区：
文献类型：
--
作者：
Baraniuk JN;Shivapurkar N
海湾战争病（GWI）和慢性疲劳综合征（CFS）具有相似的疼痛、疲劳、认知功能障碍和劳力性衰竭特征。运动后不适表明运动改变了中枢神经系统功能。在GWI、CFS和对照受试者中，在（i）过夜休息（非运动）或（ii）次极量自行车运动后进行腰椎穿刺。三分之一的GWI受试者出现运动诱发的体位性心动过速（应激试验激活可逆性心动过速，START）。其余为压力测试引发的幻影感知（STOPP）受试者。定量PCR扩增脑脊液中的microRNA（miRNA）。非运动GWI组（n = 22）、CFS组（n = 43）和对照组（n = 22）之间的水平相当。运动后，START组（n = 22）的miR-22- 3 p显著低于对照组（n = 15）和STOPP组（n = 42），但miR-9- 3 p高于STOPP组。与非运动组相比，所有运动后组的miR-328和miR-608显著减少;这些可能是运动对大脑影响的标志物。与非运动组相比，运动后START，STOPP和对照组中有6种miRNAs显著升高，12种减少。CFS在运动后有12个miRNAs减少。尽管CFS、GWI和其他疾病在鉴别诊断中有症状重叠，但脑脊液中运动诱导的miRNA模式表明CFS和GWI的START和STOPP表型中运动后不适的不同机制。
Gulf War Illness (GWI) and Chronic Fatigue Syndrome (CFS) have similar profiles of pain, fatigue, cognitive dysfunction and exertional exhaustion. Post-exertional malaise suggests exercise alters central nervous system functions. Lumbar punctures were performed in GWI, CFS and control subjects after (i) overnight rest (nonexercise) or (ii) submaximal bicycle exercise. Exercise induced postural tachycardia in one third of GWI subjects (Stress Test Activated Reversible Tachycardia, START). The remainder were Stress Test Originated Phantom Perception (STOPP) subjects. MicroRNAs (miRNA) in cerebrospinal fluid were amplified by quantitative PCR. Levels were equivalent between nonexercise GWI (n = 22), CFS (n = 43) and control (n = 22) groups. After exercise, START (n = 22) had significantly lower miR-22-3p than control (n = 15) and STOPP (n = 42), but higher miR-9-3p than STOPP. All post-exercise groups had significantly reduced miR-328 and miR-608 compared to nonexercise groups; these may be markers of exercise effects on the brain. Six miRNAs were significantly elevated and 12 diminished in post-exercise START, STOPP and control compared to nonexercise groups. CFS had 12 diminished miRNAs after exercise. Despite symptom overlap of CFS, GWI and other illnesses in their differential diagnosis, exercise-induced miRNA patterns in cerebrospinal fluid indicated distinct mechanisms for post-exertional malaise in CFS and START and STOPP phenotypes of GWI.
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影响因子：
3.9
作者：
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DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
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作者：
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通讯作者：
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