White matter hyperintensity longitudinal morphometric analysis in association with Alzheimer disease
White matter hyperintensity longitudinal morphometric analysis in association with Alzheimer disease
复制标题
与阿尔茨海默病相关的白质高信号纵向形态测量分析
DOI：
10.1002/alz.13377
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
An, Hongyu
中科院分区：
文献类型：
--
作者：
Strain, Jeremy Fuller;Phuah, Chia‐Ling;Adeyemo, Babatunde;Cheng, Kathleen;Womack, Kyle B.;McCarthy, John;Goyal, Manu;Chen, Yasheng;Sotiras, Aristeidis;An, Hongyu
引言阿尔茨海默病（AD）的血管损伤显示出相互矛盾的结果，特别是在分析纵向数据时。我们介绍了白色高信号（WMH）纵向形态计量分析（WLMA），量化WMH扩展作为从病变体素到感兴趣区域边界的距离。METHODSWMH分割图来自270个纵向液体衰减反转恢复（FLAIR）ADNI图像。对具有不同空间分布的五种数据驱动的WMH模式进行了WLMA。淀粉样蛋白的积累与WMH扩张在五个WMH模式进行了评估。结论：与对照组相比，临床前组在后心室WM中具有显著更大的扩张。淀粉样蛋白与AD患者额叶WMH扩张显著相关。WLMA优于WMH体积变化，用于将AD与对照分类，主要是在脑室周围和后部WMH中。这些数据支持这样的概念，即局部WMH扩张继续增殖，淀粉样蛋白积聚在整个疾病的不同空间位置。
INTRODUCTIONVascular damage in Alzheimer's disease (AD) has shown conflicting findings particularly when analyzing longitudinal data. We introduce white matter hyperintensity (WMH) longitudinal morphometric analysis (WLMA) that quantifies WMH expansion as the distance from lesion voxels to a region of interest boundary.METHODSWMH segmentation maps were derived from 270 longitudinal fluid‐attenuated inversion recovery (FLAIR) ADNI images. WLMA was performed on five data‐driven WMH patterns with distinct spatial distributions. Amyloid accumulation was evaluated with WMH expansion across the five WMH patterns.RESULTSThe preclinical group had significantly greater expansion in the posterior ventricular WM compared to controls. Amyloid significantly associated with frontal WMH expansion primarily within AD individuals. WLMA outperformed WMH volume changes for classifying AD from controls primarily in periventricular and posterior WMH.DISCUSSIONThese data support the concept that localized WMH expansion continues to proliferate with amyloid accumulation throughout the entirety of the disease in distinct spatial locations.
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影响因子：
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作者：
Brickman, Adam M.;Provenzano, Frank A.;Muraskin, Jordan;Manly, Jennifer J.;Blum, Sonja;Apa, Zoltan;Stern, Yaakov;Brown, Truman R.;Luchsinger, Jose A.;Mayeux, Richard
通讯作者：
Mayeux, Richard
DOI：
--
发表时间：
2017
期刊：
--
影响因子：
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作者：
C. Jack;D. Bennett;K. Blennow;B. Dunn;C. Elliott;S. Haeberlein;D. Holtzman;M. Jagust;F. Jessen-F.
通讯作者：
C. Jack;D. Bennett;K. Blennow;B. Dunn;C. Elliott;S. Haeberlein;D. Holtzman;M. Jagust;F. Jessen-F.
脑脊液淀粉样蛋白是从衰老到阿尔茨海默病的整个病程中白质高信号的一致预测因子
影响因子：
4.2
作者：
Phoebe Walsh;C. Sudre;Cassidy M. Fiford;N. Ryan;T. Lashley;C. Frost;J. Barnes
通讯作者：
J. Barnes
影响因子：
12.7
作者：
McAleese KE;Miah M;Graham S;Hadfield GM;Walker L;Johnson M;Colloby SJ;Thomas AJ;DeCarli C;Koss D;Attems J
通讯作者：
Attems J
影响因子：
--
作者：
Carmichael, Owen;Schwarz, Christopher;Drucker, David;Fletcher, Evan;Harvey, Danielle;Beckett, Laurel;Jack, Clifford R.;Weiner, Michael;DeCarli, Charles
通讯作者：
DeCarli, Charles