Glycemic control, inflammation, and cognitive function in older patients with type 2 diabetes.
Glycemic control, inflammation, and cognitive function in older patients with type 2 diabetes.
复制标题
DOI：
10.1002/gps.4267
复制
发表时间：
2015-10
影响因子：
4
通讯作者：
Schnaider Beeri M
中科院分区：
文献类型：
--
作者：
Akrivos J;Ravona-Springer R;Schmeidler J;LeRoith D;Heymann A;Preiss R;Hoffman H;Koifman K;Silverman JM;Schnaider Beeri M
糖化血红蛋白（HbA 1c）和C反应蛋白（CRP）与认知功能障碍独立相关。然而，目前还不清楚它们的组合是否会加剧认知功能的不良。我们在一个认知正常的2型糖尿病老年人样本中评估了长期血糖水平和血糖变异性是否调节了全身炎症与认知功能的关系。一项回顾性队列研究，随机选择了777名参与者，来自Maccabi医疗保健服务糖尿病登记处的约11，000名患者，作为以色列糖尿病和认知衰退研究的一部分。在Maccabi Healthcare Services Registry中，受试者的平均HbA 1c测量值为18（±9.4），用于计算长期血糖水平（HbA 1c平均值）和血糖变异性（HbA 1c标准差（SD））。线性回归模型评估了CRP（全身炎症的标志物）与HbA 1c-mean和HbA 1c-SD对受试者在记忆、执行功能、注意力和语义分类测试中表现的相互作用。CRP与HbA 1c-SD的二次交互作用对执行功能和整体认知具有重要意义。然而，Bonferroni校正后，CRP与HbA 1c的相互作用均无统计学显著性。在根据HbA 1c-SD三分位数的偏相关中，CRP在中间三分位数与语义分类（r =-0.166，p = 0.011）、执行功能（r =-0.136，p = 0.038）和整体认知（r =-0.157，p = 0.016）领域的表现下降呈弱相关。糖化血红蛋白并不能显著调节认知功能正常、社区居住的2型糖尿病老年人样本中CRP与认知功能的相关性。
Glycated hemoglobin (HbA1c) and C-reactive protein (CRP) have been associated with cognitive impairment independently. However, it is unclear if their combination exacerbates poor cognitive function. We assessed whether long-term glycemic level and glycemic variability modulate the association of systemic inflammation with cognitive function, in a sample of cognitively normal older people with type 2 diabetes. A retrospective cohort study of 777 randomly selected participants from ~11,000 patients in the Maccabi Healthcare Services Diabetes Registry, as part of the Israel Diabetes and Cognitive Decline study. Subjects averaged 18 (±9.4) HbA1c measures in the Maccabi Healthcare Services Registry, which were used to calculate long-term glycemic level (HbA1c-mean) and glycemic variability (HbA1c-standard deviation (SD)). Linear regression models assessed the interactions of CRP, a marker of systemic inflammation, with HbA1c-mean and HbA1c-SD on subjects’ performance in tests of Memory, Executive Functions, Attention, and Semantic Categorization. Quadratic interactions of CRP with HbA1c-SD approached significance for executive functions and overall cognition. However, after Bonferroni adjustment, none of the interactions of CRP with HbA1c were statistically significant. In partial correlations according to HbA1c-SD tertiles, CRP was weakly correlated in the middle tertile with decreased performance in the domains of semantic categorization (r = −0.166, p = 0.011), executive functions (r = −0.136, p = 0.038), and overall cognition (r = −0.157, p = 0.016). Glycated hemoglobin does not substantially modulate the association of CRP with cognition in a sample of cognitively normal, community dwelling older people with relatively well-managed type 2 diabetes.
登录
查看更多内容
影响因子：
16.2
作者：
Monnier, Louis;Colette, Claude
通讯作者：
Colette, Claude
影响因子：
7.2
作者：
West, Rebecca K.;Ravona-Springer, Ramit;Schnaider-Beeri, Michal
通讯作者：
Schnaider-Beeri, Michal
影响因子：
3.5
作者：
Zhong Yuan;Zhang Xiao Yan;Jia Wei Ping
通讯作者：
Jia Wei Ping
影响因子：
9.9
作者：
Beeri, M. S.;Schmeidler, J.;Haroutunian, V.
通讯作者：
Haroutunian, V.
影响因子：
158.5
作者：
Holman, Rury R.;Paul, Sanjoy K.;Neil, H. Andrew W.
通讯作者：
Neil, H. Andrew W.