Methods to study chaperone-mediated autophagy.
Methods to study chaperone-mediated autophagy.
复制标题
研究伴侣介导的自噬的方法。
DOI：
10.1016/j.ymeth.2015.01.003
复制
发表时间：
2015-03
期刊：
影响因子：
4.8
通讯作者：
Cuervo, Ana Maria
中科院分区：
文献类型：
--
作者：
Patel, Bindi;Cuervo, Ana Maria
Chaperone-mediated autophagy (CMA) is a multistep process that involves selective degradation and digestion of a pool of soluble cytosolic proteins in lysosomes. Cytosolic substrates are selectively identified and targeted by chaperones to lysosomes where they are subsequently translocated into the organelle lumen through a dedicated CMA-associated lysosomal membrane receptor/translocation complex. CMA contributes to maintaining a functional proteome, through elimination of altered proteins, and participates in the cellular energetic balance through amino acid recycling. Defective or dysfunctional CMA has been associated with human pathologies such as neurodegeneration, cancer, immunodeficiency or diabetes, increasing the overall interest in methods to monitor this selective autophagic pathway. Here, we describe approaches used to study CMA in different experimental models.
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影响因子：
16.6
作者：
通讯作者：
--
影响因子：
13.3
作者：
Finn, Patrick E.;Mesires, Nicholas T.;Dice, J. Fred
通讯作者：
Dice, J. Fred
DOI：
10.1083/jcb.137.4.825
发表时间：
1997-05-19
期刊：
The Journal of cell biology
影响因子：
--
作者：
Agarraberes FA;Terlecky SR;Dice JF
通讯作者：
Dice JF
影响因子：
5.6
作者：
AUTERI, JS;OKADA, A;DICE, JF
通讯作者：
DICE, JF
影响因子：
5.3
作者：
Bandyopadhyay, Urmi;Kaushik, Susmita;Cuervo, Ana Maria
通讯作者：
Cuervo, Ana Maria