Characterization of a versatile organometallic pro-drug (CORM) for experimental CO based therapeutics.
Characterization of a versatile organometallic pro-drug (CORM) for experimental CO based therapeutics.
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DOI：
10.1039/c2dt32174b
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发表时间：
2013-05-07
期刊：
影响因子：
--
通讯作者：
Romão CC
中科院分区：
文献类型：
--
作者：
Seixas JD;Mukhopadhyay A;Santos-Silva T;Otterbein LE;Gallo DJ;Rodrigues SS;Guerreiro BH;Gonçalves AM;Penacho N;Marques AR;Coelho AC;Reis PM;Romão MJ;Romão CC
据报道，复合物fac-[Mo（CO）3（histidinate）]Na在体内是一种有效的CO−释放分子，在几种动物疾病模型中产生治疗作用。该复合物在体外和体内不同环境中的CO释放曲线表明，该化合物在生物条件下可以容易地释放其所有三种CO当量。该化合物具有低毒性和细胞毒性，并且不具有溶血性。CO释放伴随着体内给药后动脉血压的降低。我们研究了它在溶液中的行为以及与蛋白质的相互作用。活性氧（ROS）的产生后，暴露于空气中和多钼酸盐形成浸泡与溶菌酶晶体被观察到的复杂的分解和CO的释放的过程。
The complex fac-[Mo(CO)3(histidinate)]Na has been reported to be an effective CO− Releasing Molecule in vivo, eliciting therapeutic effects in several animal models of disease. The CO releasing profile of this complex in different settings both in vitro and in vivo reveals that the compound can readily liberate all of its three CO equivalents under biological conditions. The compound has low toxicity and cytoxicity and is not hemolytic. CO release is accompanied by a decrease in arterial blood pressure following administration in vivo. We studied its behavior in solution and upon the interaction with proteins. Reactive oxygen species (ROS) generation upon exposure to air and polyoxomolybdate formation in soaks with lysozyme crystals were observed as processes ensuing from the decomposition of the complex and the release of CO.
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DOI：
10.1107/s0907444904019158
发表时间：
2004-12-01
影响因子：
2.2
作者：
Emsley, P;Cowtan, K
通讯作者：
Cowtan, K
影响因子：
20.1
作者：
Clark, JE;Naughton, P;Motterlini, R
通讯作者：
Motterlini, R
DOI：
10.1007/s10969-007-9036-1
发表时间：
2007-09-01
期刊：
Journal of Structural and Functional Genomics
影响因子：
--
作者：
Almo, Steven C.;Bonanno, Jeffrey B.;Burley, Stephen K.
通讯作者：
Burley, Stephen K.
影响因子：
2.3
作者：
BECK, W;PETRI, W;MEDER, J
通讯作者：
MEDER, J
影响因子：
4.9
作者：
Binkley, Sarah L.;Ziegler, Christopher J.;Rowlett, Roger S.
通讯作者：
Rowlett, Roger S.