Neurodevelopment of extremely preterm infants who had necrotizing enterocolitis with or without late bacteremia.
Neurodevelopment of extremely preterm infants who had necrotizing enterocolitis with or without late bacteremia.
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DOI：
10.1016/j.jpeds.2010.05.042
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发表时间：
2010-11
影响因子：
5.1
通讯作者：
Leviton, Alan
中科院分区：
文献类型：
--
作者：
Martin, Camilia R.;Dammann, Olaf;Allred, Elizabeth N.;Patel, Sonal;O'Shea, T. Michael;Kuban, Karl C. K.;Leviton, Alan
评估坏死性小肠结肠炎（NEC）和晚期菌血症后的神经发育。样本包括1155名在妊娠23-27周出生的婴儿。NEC按照改良Bell分期标准进行分类，分为内科NEC和外科NEC。晚期菌血症定义为产后一周后血培养阳性。在矫正年龄24个月时评估神经发育。多变量模型估计发育功能障碍和小头畸形与医学或外科NEC伴或不伴晚期菌血症相关的风险。手术性NEC伴晚期菌血症的患儿精神运动发育指数<70的风险增加[OR=2.7(1.2, 6.4)]，同时伴有手术性NEC伴晚期菌血症的患儿出现双瘫性脑瘫[OR=8.4(1.9, 39)]和小头畸形[OR=9.3(2.2, 40)]的风险增加。相比之下，患有医学NEC伴或不伴晚期菌血症的儿童没有任何发育障碍的风险增加。手术NEC患儿神经发育障碍和小头畸形的风险增加，特别是如果他们也有晚期菌血症。这些观察结果支持了肠道损伤可能引发系统性炎症的假设，这种炎症可能会影响发育中的大脑。
To evaluate neurodevelopment following necrotizing enterocolitis (NEC) and late bacteremia, alone and together. Sample included 1155 infants born at 23-27 weeks’ gestation. NEC was classified by the Modified Bell’s staging criteria and grouped as medical NEC or surgical NEC. Late bacteremia was defined as a positive blood culture after the first postnatal week. Neurodevelopment was assessed at 24 months corrected age. Multivariable models estimated the risk of developmental dysfunction and microcephaly associated with medical or surgical NEC with and without late bacteremia. Children who had surgical NEC unaccompanied by late bacteremia were at increased risk of Psychomotor Developmental Indices <70 [OR=2.7 (1.2, 6.4)], and children who had both surgical NEC and late bacteremia were at increased risk of diparetic cerebral palsy [OR=8.4 (1.9, 39)] and microcephaly [OR=9.3 (2.2, 40)]. In contrast, children who had medical NEC with or without late bacteremia were not at increased risk of any developmental dysfunction. The risk of neurodevelopmental dysfunction and microcephaly is increased in children who had surgical NEC, especially if they also had late bacteremia. These observations support the hypothesis that bowel injury might initiate systemic inflammation potentially affecting the developing brain.
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影响因子：
5.1
作者：
Shah, Divyen K.;Doyle, Lex W.;Inder, Terrif E.
通讯作者：
Inder, Terrif E.
影响因子：
1.7
作者：
Soraisham, Amuchou S.;Amin, Harish J.;Sauve, Reginald S.
通讯作者：
Sauve, Reginald S.
影响因子：
2.5
作者：
Dammann, Olaf;Brinkhaus, Maria-Jantje;Darnmann, Christiane E. L.
通讯作者：
Darnmann, Christiane E. L.
影响因子：
2.1
作者：
SIMON, NP
通讯作者：
SIMON, NP
影响因子：
3.8
作者：
MORECROFT, J;SPITZ, L;HOLMES, SJK
通讯作者：
HOLMES, SJK