Influenza virus-glycan interactions.
Influenza virus-glycan interactions.
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DOI:
10.1016/j.coviro.2014.06.004
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发表时间:
2014-08
影响因子:
5.9
通讯作者:
Air, Gillian M.
中科院分区:
文献类型:
--
作者:
Air, Gillian M.
It has been known for many years that influenza viruses bind by their hemagglutinin surface glycoprotein to sialic acid (N-acetylneuraminic acid) on the surface of the host cell, and that avian viruses most commonly bind to sialic acid linked α2–3 to galactose while most human viruses bind to sialic acid in the α2–6 configuration. Over the past few years there has been a large increase in data on this binding due to technological advances in glycan binding assays, reverse genetic systems for influenza and in X-ray crystallography. The results show some surprising changes in binding specificity that do not appear to affect the ability of the virus to infect host cells.
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