Can physiology zap therapeutic sweet spots in hypertension?
Can physiology zap therapeutic sweet spots in hypertension?
复制标题
生理学可以消除高血压的治疗最佳点吗？
DOI：
10.1161/hypertensionaha.112.202754
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Joyner,MichaelJ
中科院分区：
文献类型：
--
作者：
Joyner,MichaelJ
在某种程度上，以导管为基础的肾去神经支配是药物前时代用于治疗高血压的各种形式的外科交感神经切除术的远亲。肾去神经支配也不是唯一正在出现的高血压器械治疗。颈动脉窦神经刺激引起血压反射性降低也被研究作为治疗顽固性高血压的手段。这种方法也使早期的想法重新焕发活力，许多关于患者选择和适应症蔓延的相同问题也适用于它。无论这些特定技术的命运如何，我们都应该记住，早期治疗高血压的戏剧性药物试验使用的是可能被称为交感神经溶解剂的药物。也许需要更多地思考如何调节人类高血压的交感神经系统，以及确定如何保持研究界在人类中进行基于生理的表型分析的能力，这对于找到复杂疾病的治疗最佳点是必要的。16
At some level, catheter-based renal denervation is a distant relative of various forms of surgical sympathectomy that were used in the predrug era to treat hypertension. 12 Renal denervation is also not the only device therapy for hypertension that is emerging. Carotid sinus nerve stimulation to evoke reflex reductions in blood pressure is also being studied as means to treat resistant hypertension. 13 This approach also revivifies ideas from an earlier era, and many of the same questions about patient selection and indication creep also apply to it. 14 Whatever the fate of these specific technologies, we would all do well to remember that the early and dramatic drug trials in hypertension used drugs that might be called sympatholytic. 15 Perhaps more thought about how to modulate the sympathetic nervous system in human hypertension is needed, as well as determining how to preserve the ability of the research community to do the physiologically based phenotyping in humans that is necessary to find therapeutic sweet spots for complex diseases. 16
人类的交感神经系统和血压：调节的个性化模式及其含义。
影响因子：
8.3
作者：
Joyner, Michael J.;Charkoudian, Nisha;Wallin, B. Gunnar
通讯作者：
Wallin, B. Gunnar
影响因子：
9
作者：
GRIMSON, KS;ORGAIN, ES;LONGINO, FH
通讯作者：
LONGINO, FH
影响因子：
9.8
作者：
Dengel, DR;Hagberg, JM;Goldberg, AP
通讯作者：
Goldberg, AP