Structure-function clustering in weighted brain networks.
Structure-function clustering in weighted brain networks.
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DOI：
10.1038/s41598-022-19994-9
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发表时间：
2022-10-06
影响因子：
4.6
通讯作者：
O'Dea, Reuben D.
中科院分区：
文献类型：
--
作者：
Crofts, Jonathan J.;Forrester, Michael;Coombes, Stephen;O'Dea, Reuben D.
功能网络通常描述大脑皮层的活动模式，在神经科学中被广泛研究。这些网络的动态特征，特别是它们与相对静态结构网络的偏离，被认为是高级大脑功能的关键。这种结构网络与涌现功能之间的相互作用以及多模态神经成像方法和基于频带的共同分析激发了多层网络方法。然而，许多这样的研究依赖于任意的阈值选择，将密集的加权网络转换为稀疏的二元结构。在这里，我们推广了一种多路聚类的度量来描述具有任意多层的加权多路。此外，我们将最近开发的结构-功能聚类测量（描述解剖连接和功能网络之间的差异）扩展到加权情况。为了证明它的实用性，我们将人类连接组数据与模拟神经活动和分岔分析相结合。我们的结果表明，这种新的措施可以提取神经相关的特征不容易明显在类似的单层分析。特别是，我们能够推断出神经活动的多稳定模式出现的动态机制。重要的是，这些发现表明，除了临界之外，大脑操作还能促进认知灵活性。
Functional networks, which typically describe patterns of activity taking place across the cerebral cortex, are widely studied in neuroscience. The dynamical features of these networks, and in particular their deviation from the relatively static structural network, are thought to be key to higher brain function. The interactions between such structural networks and emergent function, and the multimodal neuroimaging approaches and common analysis according to frequency band motivate a multilayer network approach. However, many such investigations rely on arbitrary threshold choices that convert dense, weighted networks to sparse, binary structures. Here, we generalise a measure of multiplex clustering to describe weighted multiplexes with arbitrarily-many layers. Moreover, we extend a recently-developed measure of structure-function clustering (that describes the disparity between anatomical connectivity and functional networks) to the weighted case. To demonstrate its utility we combine human connectome data with simulated neural activity and bifurcation analysis. Our results indicate that this new measure can extract neurologically relevant features not readily apparent in analogous single-layer analyses. In particular, we are able to deduce dynamical regimes under which multistable patterns of neural activity emerge. Importantly, these findings suggest a role for brain operation just beyond criticality to promote cognitive flexibility.
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DOI：
10.1177/1073858416667720
发表时间：
2017-10
期刊：
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry
影响因子：
--
作者：
Bassett DS;Bullmore ET
通讯作者：
Bullmore ET
影响因子：
16.2
作者：
Fries P
通讯作者：
Fries P
使用功能连接对脑部疾病进行分类和预测：有希望但具有挑战性
影响因子：
4.3
作者：
Du Y;Fu Z;Calhoun VD
通讯作者：
Calhoun VD
影响因子：
5.3
作者：
Deco, Gustavo;Ponce-Alvarez, Adrian;Corbetta, Maurizio
通讯作者：
Corbetta, Maurizio
影响因子：
3.7
作者：
Allen, Elena A.;Damaraju, Eswar;Calhoun, Vince D.
通讯作者：
Calhoun, Vince D.