Efficient DNA-Mediated Electron Transport in Ionic Liquids
Efficient DNA-Mediated Electron Transport in Ionic Liquids
复制标题
离子液体中 DNA 介导的高效电子传输
DOI：
10.1021/acssuschemeng.6b01605
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发表时间：
2016
影响因子：
8.4
通讯作者：
Fangwei Shao
中科院分区：
文献类型：
--
作者：
Shuguang Xuan;Zhenyu Meng;Xiangyang Wu;J. Wong;Gitali Devi;E. K. Yeow;Fangwei Shao
双链DNA的电子导电性在构建DNA基生物传感器和仿生太阳能电池等电子器件方面有着广阔的应用前景。然而，在水溶液中，DNA介导的电子转移（ET）对于这些应用来说往往远非理想。我们在这里报道，在水合离子液体（IL）中，电子可以通过4 nm的双链体DNA的传播，并在更长的距离上实现更高的ET效率，这产生了非典型的负距离衰减参数（γ = −0.02 A-1）。荧光研究和ET效率的双链体DNA在IL-D2 O显示，结合的阳离子和阴离子种类的水合IL在DNA小沟和排除水从DNA水合层显着提高碱基对堆叠的双链体DNA，以实现有效的导电性。作为核酸的氧化反应，高效的DNA ET表明IL可能是生物大分子氧化还原反应的一种有前途的非有机和非水溶剂。
Electron conductivity of duplex DNA has promising applications in fabricating DNA based biosensors and electronic devices for biomimic solar cells. However, in aqueous solution DNA-mediated electron transfer (ET) is often far from ideal for these applications. We reported here that in hydrated ionic liquids (IL) electron can propagate through 4 nm of duplex DNA, and higher ET efficiency was achieved over longer distance which yielded a noncanonical negative distance decay parameter (γ = −0.02 A–1). Fluorescence studies and ET efficiency of duplex DNA in IL-D2O revealed that the binding of both cationic and anionic species of hydrated IL in DNA minor groove and the exclusion of water from the DNA hydration layer significantly improved base-pair stacking of duplex DNA to achieve efficient electric conductivity. As an oxidation reaction of nucleic acids, efficient DNA ET observed here suggested that IL could be a promising nonorganic and nonaqueous solvent for redox reactions of biomacromolecules.
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影响因子：
3.4
作者：
Hua Zhao
通讯作者：
Hua Zhao
影响因子：
62.1
作者：
Kumar, Anil;Sevilla, Michael D.
通讯作者：
Sevilla, Michael D.
影响因子：
15
作者：
Shao, FW;Augustyn, K;Barton, JK
通讯作者：
Barton, JK
影响因子：
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作者：
Núñez, ME;Hall, DB;Barton, JK
通讯作者：
Barton, JK