Piezoelectric Nanoparticle-Assisted Wireless Neuronal Stimulation.
Piezoelectric Nanoparticle-Assisted Wireless Neuronal Stimulation.
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DOI：
10.1021/acsnano.5b03162
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发表时间：
2015-07-28
期刊：
影响因子：
17.1
通讯作者：
Ciofani, Gianni
中科院分区：
文献类型：
--
作者：
Marino, Attilio;Arai, Satoshi;Hou, Yanyan;Sinibaldi, Edoardo;Pellegrino, Mario;Chang, Young-Tae;Mazzolai, Barbara;Mattoli, Virgilio;Suzuki, Madoka;Ciofani, Gianni
钛酸四钡纳米颗粒（BTNP）由于其压电性质而被开发为纳米换能器，以向SH-SY 5 Y神经元样细胞提供间接电刺激。在将超声波应用于用BTNP处理的细胞后，离子动力学的荧光成像显示，协同刺激能够在钙和钠通量方面引起显著的细胞反应;此外，用适当的阻断剂进行的测试表明，电压门控膜通道被激活。神经元样细胞的压电刺激的假设是支持的立方nonpiezoelectric BTNP的存在下缺乏细胞反应，并进一步证实了一个简单的电弹性模型的BTNP进行超声波，根据所产生的电压是兼容的电压敏感通道的激活所需的值。
Tetragonal barium titanate nanoparticles (BTNPs) have been exploited as nanotransducers owing to their piezoelectric properties, in order to provide indirect electrical stimulation to SH-SY5Y neuron-like cells. Following application of ultrasounds to cells treated with BTNPs, fluorescence imaging of ion dynamics revealed that the synergic stimulation is able to elicit a significant cellular response in terms of calcium and sodium fluxes; moreover, tests with appropriate blockers demonstrated that voltage-gated membrane channels are activated. The hypothesis of piezoelectric stimulation of neuron-like cells was supported by lack of cellular response in the presence of cubic nonpiezoelectric BTNPs, and further corroborated by a simple electroelastic model of a BTNP subjected to ultrasounds, according to which the generated voltage is compatible with the values required for the activation of voltage-sensitive channels.
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影响因子：
7.7
作者：
Brunoni, Andre Russowsky;Nitsche, Michael A.;Bolognini, Nadia;Bikson, Marom;Wagner, Tim;Merabet, Lotfi;Edwards, Dylan J.;Valero-Cabre, Antoni;Rotenberg, Alexander;Pascual-Leone, Alvaro;Ferrucci, Roberta;Priori, Alberto;Boggio, Paulo Sergio;Fregni, Felipe
通讯作者：
Fregni, Felipe
DOI：
10.1523/jneurosci.4190-10.2010
发表时间：
2010-11-10
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Knöpfel T;Lin MZ;Levskaya A;Tian L;Lin JY;Boyden ES
通讯作者：
Boyden ES
DOI：
10.2142/biophysics.10.109
发表时间：
2014
期刊：
Biophysics (Nagoya-shi, Japan)
影响因子：
--
作者：
Itoh H;Oyama K;Suzuki M;Ishiwata S
通讯作者：
Ishiwata S
影响因子：
4.6
作者：
Arai S;Lee SC;Zhai D;Suzuki M;Chang YT
通讯作者：
Chang YT
影响因子：
--
作者：
Ciofani, Gianni;Danti, Serena;D'Alessandro, Delfo;Moscato, Stefania;Petrini, Mario;Menciassi, Arianna
通讯作者：
Menciassi, Arianna