The Role of Immune Factors in Shaping Fetal Neurodevelopment.
The Role of Immune Factors in Shaping Fetal Neurodevelopment.
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免疫因子在塑造胎儿神经发育中的作用。
DOI：
10.1146/annurev-cellbio-021120-033518
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发表时间：
2020-10-06
影响因子：
11.3
通讯作者：
Iwasaki, Akiko
中科院分区：
文献类型：
--
作者：
Lu-Culligan, Alice;Iwasaki, Akiko
胎儿在子宫内的神经发育是由母体的全身免疫和母胎界面的局部过程深刻塑造的。免疫途径是妊娠期正常生理的重要参与者，在此期间由于感染而引起的母体免疫紊乱越来越多地与各种不良神经系统结局有关，包括在出生后很晚才出现的疾病。虽然母体免疫激活（MIA）的实验模型提供了开创性的特征的母体途径的发病机制，不太常见的检查是在胚胎和胎儿的病原体独立的发育功能的免疫因子。在这篇综述中，我们探讨了什么是已知的免疫因子在正常妊娠期间胎儿神经发育的体内作用，并提供了一个概述MIA如何扰乱这一序列的事件的适当编排。最后，我们讨论了免疫因子的失调如何可能有助于各种神经系统疾病的表现。
Fetal neurodevelopment in utero is profoundly shaped by both systemic maternal immunity and local processes at the maternal–fetal interface. Immune pathways are a critical participant in the normal physiology of pregnancy and perturbations of maternal immunity due to infections during this period have been increasingly linked to a diverse array of poor neurological outcomes, including diseases that manifest much later in postnatal life. While experimental models of maternal immune activation (MIA) have provided groundbreaking characterizations of the maternal pathways underlying pathogenesis, less commonly examined are the immune factors that serve pathogen-independent developmental functions in the embryo and fetus. In this review, we explore what is known about the in vivo role of immune factors in fetal neurodevelopment during normal pregnancy and provide an overview of how MIA perturbs the proper orchestration of this sequence of events. Finally, we discuss how the dysregulation of immune factors may contribute to the manifestation of a variety of neurological disorders.
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