Resistance to oxidative stress is not associated with the exceptional longevity of the freshwater pearl mussel, Margaritifera margaritifera nor three unionid species
Resistance to oxidative stress is not associated with the exceptional longevity of the freshwater pearl mussel, Margaritifera margaritifera nor three unionid species
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对氧化应激的抵抗力与淡水珍珠贻贝、Margaritifera margaritifera 或三种 Unionid 物种的超长寿命无关
DOI：
10.1007/s00027-013-0334-3
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发表时间：
2013
期刊：
影响因子：
2.4
通讯作者：
Ridgway I
中科院分区：
文献类型：
--
作者：
Ridgway I
双壳类软体动物是新发现的成功衰老的模式。在这里，我们测试了淡水贻贝极端长寿与增强对氧化应激的抵抗力的假设。我们评估了对氧化应激的抵抗是否可能与淡水珍珠Margaritifera Margaritifera表现出的异常长寿有关。我们比较了对氧化应激的抵抗力和血细胞总数，这是一种健康状态的生物标记物。Mararitifera(最大潜在寿命1.9亿年)与其他三种淡水双壳类物种的寿命跨度范围。以前对海洋双壳类的相对抗逆性和寿命的研究为长寿之间的假设提供了证据，该假说不仅与提高对氧化应激的抵抗力有关，而且与对多种应激源的普遍抵抗力有关。我们比较了基线血细胞总数、与年龄相关的变化以及对氧化应激、叔丁基氢过氧化氢(TBHP)暴露的反应。令人惊讶的是，我们的数据并不支持INM超长寿的假设。玛格丽蒂菲与增强对氧化应激的抵抗力有关。与寿命较短的对应物相比，Mararitifera对氧化应激的抵抗力最低。在接触TBHP后，没有观察到寿命与抵抗氧化应激诱导的死亡率之间的联系，也没有观察到对氧化应激诱导的血细胞总数下降的显著抵抗。结果表明，淡水贻贝的寿命是单独进化的，这一组值得生物老年学家进一步关注，因为这种研究可能会提供新的见解，而不是通过对这一纲的海洋成员的研究发现的，而这一类目前最受关注。
Bivalve molluscs are newly discovered models of successful ageing. Here, we test the hypothesis that extreme longevity of freshwater mussels is associated with an enhanced resistance to oxidative stress. We assess whether resistance to oxidative stress might be causally involved in the exceptional longevity exhibited by the freshwater pearl musselMargaritifera margaritifera. We compared resistance to oxidative stress and total haemocyte counts, a health status biomarker inM. margaritifera(maximum lifespan potential 190 years) with three other freshwater bivalve species spanning a range of longevities. Previous studies of the comparative stress resistance and longevity of marine bivalves provide evidence for the hypothesis that an association exists between longevity and not only an enhanced resistance to oxidative stress but also a general resistance to multiplex stressors. We compared baseline total haemocyte counts, age-related changes, and responses to exposure to the oxidative stressortert-butyl hydroperoxide (TBHP). Surprisingly our data does not support the premise that extreme longevity inM. margaritiferais associated with enhanced resistance to oxidative stress. In comparison with its shorter-lived counter partsM.margaritiferawas the least resistance to oxidative stress. Following TBHP exposure, no association between longevity and resistance to oxidative stress-induced mortality nor a marked resistance to oxidative stress-induced declines in total haemocyte counts were observed. The results suggest longevity evolved separately in freshwater mussels and this group warrants further attention from biogerontologists because such study may provide novel insights not detected through the study of the marine members of the class, where most attention is currently focused.
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DOI：
--
发表时间：
1978
期刊：
影响因子：
--
作者：
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通讯作者：
L. Johnson
DOI：
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期刊：
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DOI：
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发表时间：
2000
期刊：
The journals of gerontology. Series A, Biological sciences and medical sciences
影响因子：
--
作者：
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通讯作者：
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DOI：
--
发表时间：
2009
期刊：
影响因子：
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作者：
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通讯作者：
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DOI：
--
发表时间：
1988
期刊：
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