The first 9 years of kidney paired donation through the National Kidney Registry: Characteristics of donors and recipients compared with National Live Donor Transplant Registries.
The first 9 years of kidney paired donation through the National Kidney Registry: Characteristics of donors and recipients compared with National Live Donor Transplant Registries.
复制标题
DOI：
10.1111/ajt.14744
复制
发表时间：
2018-11
期刊：
影响因子：
--
通讯作者：
Waterman AD
中科院分区：
文献类型：
--
作者：
Flechner SM;Thomas AG;Ronin M;Veale JL;Leeser DB;Kapur S;Peipert JD;Segev DL;Henderson ML;Shaffer AA;Cooper M;Hil G;Waterman AD
肾脏配对捐赠（KPD）的实践每年都在扩大，为更多患者提供了活体肾脏移植的机会。我们试图确定自愿KPD网络，如国家肾脏登记处（NKR），与国家登记处相比，是否选择或吸引了更窄的供体或受体群体。为此，我们将2008年2月14日至2017年2月14日NKR数据库与SRTR数据库的数据合并，涵盖了NKR的前9年。与所有UNOS活体供体移植（49，610例）、所有UNOS活体非亲缘移植（23，319例）和所有其他KPD移植（4，236例）相比，NKR移植（2，037例）的人口统计学和临床特征似乎与当代国家趋势相似。特别是，在NKR患者中，（p <0.001）再次移植数量更多（25.6 vs. 11.5%），超免疫接种者（22.7 vs. 4.3% cPRA >80%），女性（45.9 vs. 37.6%），黑人接受者（18.2 vs. 13%），以及公共保险接受者（49.7 vs. 41.8%）。这些结果支持需要更大的共享和更大的池大小，也许通过进入兼容的配对甚至由已故捐赠者发起的链来增强，为那些难以匹配的配对解锁更多的机会。
The practice of kidney paired donation (KPD) is expanding annually, offering the opportunity for live donor kidney transplantation to more patients. We sought to identify if voluntary KPD networks such as the National Kidney Registry (NKR) were selecting or attracting a narrower group of donors or recipients compared to national registries. For this purpose, we merged data from the NKR database with the SRTR database from February 14, 2008 to February 14, 2017, encompassing the first 9 years of the NKR. When compared to all UNOS live donor transplants (49,610), all UNOS living unrelated transplants (23,319), and all other KPD transplants (4,236), the demographic and clinical characteristics of NKR transplants (2,037) appear similar to contemporary national trends. In particular, among the NKR patients there were a significantly (p <0.001) greater number of retransplants (25.6 vs. 11.5%), hyperimmunized recipients (22.7 vs. 4.3% were cPRA >80%), females (45.9 vs. 37.6%), black recipients (18.2 vs. 13%), and those on public insurance (49.7 vs. 41.8%) compared to controls. These results support the need for greater sharing and larger pool sizes, perhaps enhanced by entry of compatible pairs and even chains initiated by deceased donors, to unlock more opportunities for those harder to match pairs.
登录
查看更多内容
影响因子：
8.8
作者：
Bingaman, A. W.;Wright, F. H., Jr.;Murphey, C. L.
通讯作者：
Murphey, C. L.
影响因子：
8.8
作者：
LaPointe Rudow, D.;Hays, R.;Rodrigue, J. R.
通讯作者：
Rodrigue, J. R.
影响因子：
158.5
作者：
Orandi, B. J.;Luo, X.;Segev, D. L.
通讯作者：
Segev, D. L.
影响因子：
0.8
作者：
Jha, P K;Sethi, S;Kher, V
通讯作者：
Kher, V
影响因子：
6.2
作者：
Park, K;Moon, JI;Kim, YS
通讯作者：
Kim, YS