Differential T-Cell Reactivity to Endemic Coronaviruses and SARS-CoV-2 in Community and Health Care Workers.
Differential T-Cell Reactivity to Endemic Coronaviruses and SARS-CoV-2 in Community and Health Care Workers.
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DOI：
10.1093/infdis/jiab176
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发表时间：
2021-07-02
期刊：
影响因子：
--
通讯作者：
Sette A
中科院分区：
文献类型：
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作者：
da Silva Antunes R;Pallikkuth S;Williams E;Dawen Yu E;Mateus J;Quiambao L;Wang E;Rawlings SA;Stadlbauer D;Jiang K;Amanat F;Arnold D;Andrews D;Fuego I;Dan JM;Grifoni A;Weiskopf D;Krammer F;Crotty S;Hoffer ME;Pahwa SG;Sette A
在此，我们测量了高危医护人员 (HCW) 和社区控制人员中 CD4+ T 细胞对普通感冒冠状病毒 (CCC) 和严重急性呼吸综合征冠状病毒 2 (SARS-CoV-2) 的反应。我们观察到，与社区捐赠者相比，SARS-CoV-2 血清阴性医务人员的 CCC 反应性 T 细胞水平较高，这与医务人员对 CCC 的职业暴露可能较高一致。我们进一步表明，血清阴性 HCW 的 SARS-CoV-2 T 细胞反应性高于社区对照，并且 CCC 和 SARS-CoV-2 反应之间的相关性与交叉反应性一致，与最近的体内激活无关。令人惊讶的是，感染 SARS-CoV-2 的医护人员的 CCC T 细胞反应性降低，这表明接触 SARS-CoV-2 可能会直接或间接干扰 CCC 反应。这一结果出乎意料，但在来自迈阿密和圣地亚哥的独立队列中始终检测到。与 COVID-19 康复期医护人员相比，SARS-CoV-2 血清阴性高危医护人员 (HCW) 的 CD4+ T 细胞针对普通感冒冠状病毒 (CCC) 的反应升高，这表明接触 SARS-CoV-2 可能会干扰 CCC 反应和/或与保护作用相关的交叉反应。与 COVID-19 康复期医护人员相比，SARS-CoV-2 血清阴性高危医护人员 (HCW) 的 CD4+ T 细胞针对普通感冒冠状病毒 (CCC) 的反应升高，这表明接触 SARS-CoV-2 可能会干扰 CCC 反应和/或交叉反应，从而产生保护作用。
Herein we measured CD4+ T-cell responses against common cold coronaviruses (CCC) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in high-risk health care workers (HCW) and community controls. We observed higher levels of CCC-reactive T cells in SARS-CoV-2–seronegative HCW compared to community donors, consistent with potential higher occupational exposure of HCW to CCC. We further show that SARS-CoV-2 T-cell reactivity of seronegative HCW was higher than community controls and correlation between CCC and SARS-CoV-2 responses is consistent with cross-reactivity and not associated with recent in vivo activation. Surprisingly, CCC T-cell reactivity was decreased in SARS-CoV-2–infected HCW, suggesting that exposure to SARS-CoV-2 might interfere with CCC responses, either directly or indirectly. This result was unexpected, but consistently detected in independent cohorts derived from Miami and San Diego. CD4+ T-cell responses against common cold coronaviruses (CCC) are elevated in SARS-CoV-2 seronegative high-risk health care workers (HCW) compared to COVID-19 convalescent HCW, suggesting that exposure to SARS-CoV-2 might interfere with CCC responses and/or cross-reactivity associated with a protective effect. CD4+ T-cell responses against common cold coronaviruses (CCC) are elevated in SARS-CoV-2 seronegative high-risk health care workers (HCW) compared to COVID-19 convalescent HCW, suggesting that exposure to SARS-CoV-2 might interfere with CCC responses and/or cross-reactivity a protective effect.
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DOI：
10.4049/jimmunol.1700893
发表时间：
2017-11-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Jurtz V;Paul S;Andreatta M;Marcatili P;Peters B;Nielsen M
通讯作者：
Nielsen M
影响因子：
15.9
作者：
Antunes, Ricardo da Silva;Babor, Mariana;Sette, Alessandro
通讯作者：
Sette, Alessandro
影响因子：
5.4
作者：
Grifoni, Alba;Voic, Hannah;Sette, Alessandro
通讯作者：
Sette, Alessandro
影响因子：
24.8
作者：
Kuri-Cervantes, Leticia;Pampena, Maria Betina;Betts, Michael R.
通讯作者：
Betts, Michael R.
影响因子：
32.4
作者：
Bonifacius A;Tischer-Zimmermann S;Dragon AC;Gussarow D;Vogel A;Krettek U;Gödecke N;Yilmaz M;Kraft ARM;Hoeper MM;Pink I;Schmidt JJ;Li Y;Welte T;Maecker-Kolhoff B;Martens J;Berger MM;Lobenwein C;Stankov MV;Cornberg M;David S;Behrens GMN;Witzke O;Blasczyk R;Eiz-Vesper B
通讯作者：
Eiz-Vesper B