Impact of bupropion and cognitive-behavioral treatment for depression on positive affect, negative affect, and urges to smoke during cessation treatment.
Impact of bupropion and cognitive-behavioral treatment for depression on positive affect, negative affect, and urges to smoke during cessation treatment.
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安非他酮和抑郁症认知行为治疗对戒烟治疗期间积极情感、消极情感和吸烟冲动的影响。
DOI：
10.1093/ntr/ntp111
复制
发表时间：
2009
期刊：
影响因子：
--
通讯作者：
Brown,RichardA
中科院分区：
文献类型：
--
作者：
Strong,DavidR;Kahler,ChristopherW;Leventhal,AdamM;Abrantes,AnaM;Lloyd-Richardson,Elizabeth;Niaura,Raymond;Brown,RichardA
安非他酮和认知行为治疗（CBT）抑郁症已被用作治疗的组成部分，旨在减轻戒烟期间的情感障碍。需要研究治疗相关的变化，在旋进影响或敦促吸烟，以评估这些treatments.MethodsThe本报告提出的机制检查情感轨迹和敦促吸烟之前，在戒烟日，在524名吸烟者中随机接受安非他酮与安慰剂以及CBT与标准戒烟CBT。或CBT并没有影响观察到的积极影响减少和消极影响增加之前停止。然而，在戒烟当天，观察到的负面影响和吸烟冲动的水平显着减少接受安非他酮的个人。戒烟前积极情绪的减少，积极情绪的降低，以及戒烟当天消极情绪和吸烟冲动的增加都与吸烟失败的风险增加有关。抑郁倾向是一个独立的预测较低的积极影响和较高的消极影响，但没有缓和安非他酮对结果的影响。在中介分析中，安非他酮的影响部分占较低的负面影响，并敦促戒烟day.DiscussionResults支持安非他酮在降低复发风险与吸烟和负面影响的冲动，并建议需要更好地了解低的积极影响的作用，早期失效的风险因素。
IntroductionBupropion and cognitive–behavioral treatment (CBT) for depression have been used as components of treatments designed to alleviate affective disturbance during smoking cessation. Studies of treatment-related changes in precessation affect or urges to smoke are needed to evaluate the proposed mechanisms of these treatments.MethodsThe present report examines affective trajectories and urges to smoke prior to, on quit day, and after quitting in a sample of 524 smokers randomized to receive bupropion versus placebo and CBT versus standard smoking cessation CBT.ResultsBupropion and/or CBT did not affect the observed decreases in positive affect and increases in negative affect prior to cessation. However, on quit day, observed levels of negative affect and urges to smoke were diminished significantly among individuals receiving bupropion. Decreases in positive affect prior to quitting, lower levels of positive affect, and increased levels of negative affect and urges to smoke on quit day were each related to higher risk of smoking lapse. Depression proneness was an independent predictor of lower positive affect and higher negative affect but did not moderate the effects of bupropion on outcomes. In mediational analyses, the effect of bupropion was accounted for in part by lower negative affect and urges to smoke on quit day.DiscussionResults support the efficacy of bupropion in reducing relapse risk associated with urges to smoke and negative affect and suggest the need to better understand the role of low positive affect as a risk factor for early lapse.
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DOI：
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