Behavioral, situational, and temporal effects of treatment of ADHD with methylphenidate.
Behavioral, situational, and temporal effects of treatment of ADHD with methylphenidate.
复制标题
哌醋甲酯治疗 ADHD 的行为、情境和时间影响。
DOI：
10.1097/00004583-199706000-00011
复制
发表时间：
1997
影响因子：
13.3
通讯作者：
P. Corkum
中科院分区：
文献类型：
--
作者：
R. Schachar;R. Tannock;Charles H. Cunningham;P. Corkum
目的
确定哌甲酯（MPH）治疗注意缺陷多动障碍（ADHD）4个月的行为、情境和时间效应。
方法
91名ADHD儿童被随机分配接受MPH（滴定至目标剂量0.7 mg/kg，每天两次）或安慰剂。通过对各种行为（核心和相关症状）、情况（家庭和学校）、时间段（上午和下午，达到目标剂量后，以及治疗4个月后）和副作用敏感的措施来研究治疗效果。
结果
MPH治疗改善了ADHD的症状和在学校的对立行为，无论是在上午和下午，但不是在家里。MPH的副作用（生理和有效症状增加，体重增加不足）明显比安慰剂治疗更常见。滴定后获益明显，但一些副作用的发生延迟。家长报告了副作用，但教师没有报告。
结论
MPH对行为的积极影响在课堂上是显而易见的，但是每天两次给予MPH，父母并没有报告说MPH改善了家里的行为。对家庭行为的更大影响可能需要每天三次MPH和联合治疗。
OBJECTIVE
To determine the behavioral, situational, and temporal effects of 4 months of methylphenidate (MPH) treatment for attention-deficit hyperactivity disorder (ADHD).
METHOD
Ninety-one children with ADHD were randomly assigned to receive either MPH (titrated to a target dose of 0.7 mg/kg twice a day) or a placebo. Treatment effects were investigated with measures sensitive to various behaviors (core and associated symptoms), situations (home and school), time periods (morning and afternoon, after reaching the target dose, and after 4 months of treatment), and side effects.
RESULTS
MPH treatment improved symptoms of ADHD and oppositional behavior at school, both in the morning and afternoon, but not at home. Side effects (increase in physiological and effective symptoms, lack of weight gain) were significantly more frequent with MPH than with placebo treatment. Benefit was evident after titration, but the onset of some side effects was delayed. Side effects were reported by parents but not by teachers.
CONCLUSIONS
Positive effects of MPH on behavior are evident in the classroom, but with MPH given twice daily, parents do not report that MPH improves behavior at home. Greater impact on home behavior may require three times daily MPH and combined treatments.
初级保健医生在治疗注意力缺陷多动障碍时使用兴奋剂药物。
影响因子：
8
作者：
Wolraich,ML;Lindgren,S;Stromquist,A;Milich,R;Davis,C;Watson,D
通讯作者：
Watson,D
使用拟交感神经药物治疗儿童注意力和多动问题：综合评价。
DOI：
10.1097/00004583-199009000-00001
发表时间：
1990
影响因子：
13.3
作者：
Jacobvitz,D;Sroufe,LA;Stewart,M;Leffert,N
通讯作者：
Leffert,N
哌醋甲酯对注意力缺陷障碍儿童的临床和认知影响作为攻击性/对立性和年龄的函数。
影响因子：
4.6
作者：
Klorman,R;Brumaghim,JT;Fitzpatrick,PA;Borgstedt,AD;Strauss,J
通讯作者：
Strauss,J