Metabolic Glycoengineering: A Promising Strategy to Remodel Microenvironments for Regenerative Therapy.
Metabolic Glycoengineering: A Promising Strategy to Remodel Microenvironments for Regenerative Therapy.
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DOI：
10.1155/2023/1655750
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发表时间：
2023
影响因子：
4.3
通讯作者：
Chen, Qixin
中科院分区：
文献类型：
--
作者：
Li, Yi;Zhang, Yuang;Tao, Yiqin;Huang, Xianpeng;Yu, Chao;Xu, Haibin;Chen, Jiangjie;Xia, Kaishun;Shi, Kesi;Zhang, Yongxiang;Wang, Jingkai;Shu, Jiawei;Cheng, Feng;Wang, Shaoke;Liang, Chengzhen;Li, Fangcai;Zhou, Xiaopeng;Chen, Qixin
基于细胞的再生疗法利用干细胞的分化潜力来恢复组织的活力。但干细胞的动态命运要求精确控制，以优化其治疗效率。干细胞的命运受称为“微环境”的特定条件控制。在微环境的各种因素中，细胞-表面多糖作为细胞-基质和细胞-细胞相互作用的中介，调控细胞的行为。因此，代谢糖工程(MGE)是一种简单但功能强大的改造糖链结构的技术。通过在表面呈现非天然的葡聚糖，MGE为我们提供了一个重塑微环境和激发所需细胞反应的机会。本文首先介绍了多糖对细胞活性的决定作用，然后介绍了MGE如何影响糖基化，进而影响细胞命运，最后概述了MGE在再生治疗中的应用，特别是在肌肉骨骼系统中的应用，并展望了MGE的未来发展方向。
Cell-based regenerative therapy utilizes the differentiation potential of stem cells to rejuvenate tissues. But the dynamic fate of stem cells is calling for precise control to optimize their therapeutic efficiency. Stem cell fate is regulated by specific conditions called “microenvironments.” Among the various factors in the microenvironment, the cell-surface glycan acts as a mediator of cell-matrix and cell-cell interactions and manipulates the behavior of cells. Herein, metabolic glycoengineering (MGE) is an easy but powerful technology for remodeling the structure of glycan. By presenting unnatural glycans on the surface, MGE provides us an opportunity to reshape the microenvironment and evoke desired cellular responses. In this review, we firstly focused on the determining role of glycans on cellular activity; then, we introduced how MGE influences glycosylation and subsequently affects cell fate; at last, we outlined the application of MGE in regenerative therapy, especially in the musculoskeletal system, and the future direction of MGE is discussed.
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影响因子：
14
作者：
Hapuarachchige, Sudath;Zhu, Wenlian;Kato, Yoshinori;Artemov, Dmitri
通讯作者：
Artemov, Dmitri
影响因子：
64.5
作者：
Dennis JW;Nabi IR;Demetriou M
通讯作者：
Demetriou M
影响因子：
7.3
作者：
Campbell CT;Aich U;Weier CA;Wang JJ;Choi SS;Wen MM;Maisel K;Sampathkumar SG;Yarema KJ
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Yarema KJ
影响因子：
4.9
作者：
Clarke LE;McConnell JC;Sherratt MJ;Derby B;Richardson SM;Hoyland JA
通讯作者：
Hoyland JA
影响因子：
14
作者：
Cheng, Hao;Byrska-Bishop, Marta;Zhang, Cathy T.;Kastrup, Christian J.;Hwang, Nathaniel S.;Tai, Albert K.;Lee, Won Woo;Xu, Xiaoyang;Nahrendorf, Matthias;Langer, Robert;Anderson, Daniel G.
通讯作者：
Anderson, Daniel G.