Randomized, placebo-controlled trial of K1 acupoint acustimulation to prevent cisplatin-induced or oxaliplatin-induced nausea.
Randomized, placebo-controlled trial of K1 acupoint acustimulation to prevent cisplatin-induced or oxaliplatin-induced nausea.
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K1 穴位针刺预防顺铂引起或奥沙利铂引起的恶心的随机、安慰剂对照试验。
DOI：
10.1002/cncr.28973
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发表时间：
2015-01-01
期刊：
影响因子：
6.2
通讯作者：
Cohen, Lorenzo
中科院分区：
文献类型：
--
作者：
Shen, Yehua;Liu, Luming;Chiang, Joseph S.;Meng, Zhiqiang;Garcia, M. Kay;Chen, Zhen;Peng, Huiting;Bei, Wenying;Zhao, Qi;Spelman, Amy R.;Cohen, Lorenzo
超过70%的癌症患者经历化疗引起的恶心和呕吐（CINV）。我们检查了电刺激位于脚底的K1穴位的效果，因为它被认为有控制CINV的潜力。在这个试验中,103例诊断为原发性或转移性肝癌招募trans-catheter动脉灌注顺铂(CDDP) (TAI)或铂(OXA),随机分为A组(N = 51;对待止吐剂tropisetron和acustimulation K1穴位20分钟,打第一天前1 - 2小时,然后每天随后5天)和B组(N = 53; tropisetron和电刺激治疗安慰剂点跟)。在基线时收集恶心和呕吐的发生率、强度和持续时间，然后在TAI后5天每天收集。每日使用MD安德森症状量表（MDASI）和EuroQoL量表评估生活质量。A组和B组在第1天或连续5天的恶心或呕吐发生率和程度无差异。A组患者的EuroQoL评分在第4天优于B组患者（A: 72.83比B: 65.94, P = 0.04），但在其他天无明显差异。MDASI评分在任何时间点均无组间差异。电刺激K1联合止吐药不能初步预防CDDP-或oxa引起的恶心或呕吐。
More than 70% of cancer patients experience chemotherapy-induced nausea and vomiting (CINV). We examined the effects of electrostimulation of the K1 acupoint located on the sole of the foot, as it is thought to have potential to control CINV. In this trial, 103 patients diagnosed with primary or metastatic liver cancer were recruited before trans-catheter arterial infusion (TAI) of cisplatin (CDDP) or oxaliplatin (OXA) and randomized to group A (N=51; treated with the antiemetic tropisetron and acustimulation at the K1 acupoint for 20 minutes, 1-2 hours before TAI on the first day and then daily for the subsequent 5 days) or group B (N=53; treated with tropisetron and electrostimulation at a placebo point on the heel). The rate, intensity, and duration of nausea and vomiting were collected at baseline and then daily for 5 days after TAI. Quality of life was assessed daily using the MD Anderson Symptom Inventory (MDASI) and the EuroQoL scale. No differences were found between groups A and B in the incidence and degree of nausea or vomiting on day 1 or the consecutive 5 days. Patients in group A had better EuroQoL scores than did patients in group B (A: 72.83 versus B: 65.94, P = 0.04) on day 4 but not on the other days. No group differences were noted at any time point for MDASI scores. Electrostimulation of K1 combined with antiemetics did not result in initial prevention of CDDP- or OXA-induced nausea or vomiting.
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影响因子：
45.3
作者：
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