Is Toll-like receptor 4 involved in the severity of COVID-19 pathology in patients with cardiometabolic comorbidities?
Is Toll-like receptor 4 involved in the severity of COVID-19 pathology in patients with cardiometabolic comorbidities?
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DOI：
10.1016/j.cytogfr.2020.09.002
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发表时间：
2021-04
影响因子：
13
通讯作者：
Aikawa M
中科院分区：
文献类型：
--
作者：
Brandão SCS;Ramos JOX;Dompieri LT;Godoi ETAM;Figueiredo JL;Sarinho ESC;Chelvanambi S;Aikawa M
严重形式的COVID-19以异常和加剧的免疫宿主反应为特征，这有利于大量患者的不良结局，特别是肥胖症、糖尿病、高血压和动脉粥样硬化患者。在这些心脏代谢合并症中发现的慢性炎症过程以促炎细胞因子如白细胞介素-6（IL-6）和肿瘤坏死因子-α（TNF-α）的过度表达为标志，这些细胞因子是Toll样受体4（TLR 4）途径的产物。SARS-CoV-2最初感染上呼吸道的细胞，在一些患者中，传播非常迅速，需要呼吸支持和全身性，造成组织的附带损害。我们推测，这是因为SARS-CoV-2刺突蛋白与TLR 4强烈相互作用，导致宿主肺部免疫反应强烈加剧，最终导致细胞因子风暴，积聚分泌物并阻碍血液氧合，沿着免疫系统攻击机体，导致多器官衰竭。
The severe form of COVID-19 is marked by an abnormal and exacerbated immunological host response favoring to a poor outcome in a significant number of patients, especially those with obesity, diabetes, hypertension, and atherosclerosis. The chronic inflammatory process found in these cardiometabolic comorbidities is marked by the overexpression of pro-inflammatory cytokines such as interleukin-6 (IL-6) and tumoral necrosis factor-alpha (TNF-α), which are products of the Toll-Like receptors 4 (TLR4) pathway. The SARS-CoV-2 initially infects cells in the upper respiratory tract and, in some patients, spread very quickly, needing respiratory support and systemically, causing collateral damage in tissues. We hypothesize that this happens because the SARS-CoV-2 spike protein interacts strongly with TLR4, causing an intensely exacerbated immune response in the host's lungs, culminating with the cytokine storm, accumulating secretions and hindering blood oxygenation, along with the immune system attacks the body, leading to multiple organ failure.
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DOI：
10.1186/1476-9255-9-48
发表时间：
2012-11-28
期刊：
Journal of inflammation (London, England)
影响因子：
--
作者：
Ahmad R;Al-Mass A;Atizado V;Al-Hubail A;Al-Ghimlas F;Al-Arouj M;Bennakhi A;Dermime S;Behbehani K
通讯作者：
Behbehani K
影响因子：
9
作者：
Channappanavar R;Perlman S
通讯作者：
Perlman S
影响因子：
5.7
作者：
Ao, Lihua;Zhai, Yufeng;Meng, Xianzhong
通讯作者：
Meng, Xianzhong
影响因子：
5.3
作者：
Boehmer, ED;Meehan, MJ;Kovacs, EJ
通讯作者：
Kovacs, EJ
影响因子：
3.1
作者：
Cao, Chao;Yin, Chengfen;Chai, Yanfen
通讯作者：
Chai, Yanfen