Pathogenic human coronavirus infections: causes and consequences of cytokine storm and immunopathology.
Pathogenic human coronavirus infections: causes and consequences of cytokine storm and immunopathology.
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DOI：
10.1007/s00281-017-0629-x
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发表时间：
2017-07
影响因子：
9
通讯作者：
Perlman S
中科院分区：
文献类型：
--
作者：
Channappanavar R;Perlman S
人冠状病毒（Human coronaviruses，hCoV）可分为低致病性和高致病性两大类。低致病性冠状病毒感染上呼吸道，引起轻微的感冒样呼吸道疾病。相比之下，高致病性hCoV如严重急性呼吸综合征CoV（SARS-CoV）和中东呼吸综合征CoV（MERS-CoV）主要感染下呼吸道并引起致命性肺炎。由致病性hCoV引起的严重肺炎通常与快速病毒复制、大量炎性细胞浸润和升高的促炎细胞因子/趋化因子应答相关，导致急性肺损伤（ALI）和急性呼吸窘迫综合征（ARDS）。最近在实验感染动物中的研究强烈表明，病毒诱导的免疫病理学事件在hCoV感染后引起致命性肺炎中起着至关重要的作用。在这里，我们回顾了目前的理解，如何失调的免疫反应可能会导致肺部免疫病理学导致有害的临床表现后，致病性hCoV感染。
Human coronaviruses (hCoVs) can be divided into low pathogenic and highly pathogenic coronaviruses. The low pathogenic CoVs infect the upper respiratory tract and cause mild, cold-like respiratory illness. In contrast, highly pathogenic hCoVs such as severe acute respiratory syndrome CoV (SARS-CoV) and Middle East respiratory syndrome CoV (MERS-CoV) predominantly infect lower airways and cause fatal pneumonia. Severe pneumonia caused by pathogenic hCoVs is often associated with rapid virus replication, massive inflammatory cell infiltration and elevated pro-inflammatory cytokine/chemokine responses resulting in acute lung injury (ALI), and acute respiratory distress syndrome (ARDS). Recent studies in experimentally infected animal strongly suggest a crucial role for virus-induced immunopathological events in causing fatal pneumonia after hCoV infections. Here we review the current understanding of how a dysregulated immune response may cause lung immunopathology leading to deleterious clinical manifestations after pathogenic hCoV infections.
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影响因子：
6.4
作者：
Alagaili AN;Briese T;Mishra N;Kapoor V;Sameroff SC;Burbelo PD;de Wit E;Munster VJ;Hensley LE;Zalmout IS;Kapoor A;Epstein JH;Karesh WB;Daszak P;Mohammed OB;Lipkin WI
通讯作者：
Lipkin WI
影响因子：
5
作者：
Cameron MJ;Bermejo-Martin JF;Danesh A;Muller MP;Kelvin DJ
通讯作者：
Kelvin DJ
影响因子：
6.7
作者：
Falzarano D;de Wit E;Feldmann F;Rasmussen AL;Okumura A;Peng X;Thomas MJ;van Doremalen N;Haddock E;Nagy L;LaCasse R;Liu T;Zhu J;McLellan JS;Scott DP;Katze MG;Feldmann H;Munster VJ
通讯作者：
Munster VJ
DOI：
10.1084/jem.20140995
发表时间：
2015-06-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Blazek K;Eames HL;Weiss M;Byrne AJ;Perocheau D;Pease JE;Doyle S;McCann F;Williams RO;Udalova IA
通讯作者：
Udalova IA
影响因子：
5.4
作者：
Cheung, CY;Poon, LLM;Peiris, JSM
通讯作者：
Peiris, JSM