Selenium-Binding Protein 1 in Human Health and Disease.
Selenium-Binding Protein 1 in Human Health and Disease.
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DOI：
10.3390/ijms19113437
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发表时间：
2018-11-02
影响因子：
5.6
通讯作者：
Diamond AM
中科院分区：
文献类型：
--
作者：
Elhodaky M;Diamond AM
硒结合蛋白1(SBP1)是一种高度保守的蛋白质，能与硒共价结合。SBP1可能在多种基本生理功能中发挥重要作用，包括蛋白质降解、高尔基体内转运、细胞分化、细胞运动、氧化还原调节和含硫分子的代谢。在许多癌症类型中，与相应的正常组织相比，SBP1的表达经常降低，并且低水平的SBP1经常与不良的临床预后有关。本文综述了SBP1的转录调控，已报道的不同生理功能，以及SBP1功能在癌症和其他疾病中的意义。
Selenium-binding protein 1 (SBP1) is a highly conserved protein that covalently binds selenium. SBP1 may play important roles in several fundamental physiological functions, including protein degradation, intra-Golgi transport, cell differentiation, cellular motility, redox modulation, and the metabolism of sulfur-containing molecules. SBP1 expression is often reduced in many cancer types compared to the corresponding normal tissues and low levels of SBP1 are frequently associated with poor clinical outcome. In this review, the transcriptional regulation of SBP1, the different physiological roles reported for SBP1, as well as the implications of SBP1 function in cancer and other diseases are presented.
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