Molecular cross-talk between members of distinct families of selenium containing proteins.
Molecular cross-talk between members of distinct families of selenium containing proteins.
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DOI：
10.1002/mnfr.201300543
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发表时间：
2014-01
影响因子：
5.2
通讯作者：
Diamond, Alan M.
中科院分区：
文献类型：
--
作者：
Ansong, Emmanuel;Yang, Wancai;Diamond, Alan M.
硒的饮食摄入与几种癌症类型的风险降低有关，这可能是由于其作为含硒蛋白质的特定成分的作用。其中之一，硒结合蛋白1（SBP 1），是一种功能未知的蛋白质，与相应的正常组织相比，其在不同组织类型的肿瘤中已显示出减少。更重要的是，据报道，SBP 1也是临床结果的预测因子。SBP 1的水平与另一种代表不同类型硒蛋白的蛋白质谷胱甘肽过氧化物酶1（GPx-1）的水平呈负相关。GPx-1是一种抗氧化剂，含有硒代半胱氨酸的酶，由于特定等位基因与疾病风险的关联，与包括癌症在内的多种疾病有关。SBP 1和GPx-1之间的关系代表了含硒蛋白质之间分子相互作用的一个独特例子，可能对人类健康和疾病产生重大影响。
Dietary intake of selenium has been associated with reduced risk of several cancer types, and this is likely due to its role as a specific constituent of selenium containing proteins. One of these, selenium binding protein 1 (SBP1), is a protein of unknown function which has been shown to be reduced in tumors of diverse tissue types as compared to the corresponding normal tissue. More importantly, SBP1 has also been reported to be a predictor of clinical outcome. Levels of SBP1 are inversely associated with the levels of another protein representative of a different class of selenoproteins, glutathione peroxidase1 (GPx-1). GPx-1 is an anti-oxidant, selenocysteine-containing enzyme implicated in several diseases, including cancer, due to the association of specific alleles with disease risk. The relationship between SBP1 and GPx-1 represents a unique example of a molecular interaction between selenium-containing proteins with a likely significant impact on human health and disease.
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影响因子：
2.8
作者：
Jerome-Morais, Anita;Wright, Margaret E.;Liu, Rui;Yang, Wancai;Jackson, Matthew I.;Combs, Gerald F., Jr.;Diamond, Alan M.
通讯作者：
Diamond, Alan M.
影响因子：
56.9
作者：
Kryukov, GV;Castellano, S;Gladyshev, VN
通讯作者：
Gladyshev, VN
影响因子：
5.2
作者：
Baliga, Manjeshwar S.;Diwadkar-Navsariwala, Veda;Diamond, Alan M.
通讯作者：
Diamond, Alan M.
影响因子：
11.5
作者：
Pass, HI;Liu, ZD;Draghici, S
通讯作者：
Draghici, S
影响因子：
11.5
作者：
Huang, Cheng;Ding, Guangyu;Fan, Jia
通讯作者：
Fan, Jia