Analysis of clinical characteristics of severe pertussis in infants and children: a retrospective study.
Analysis of clinical characteristics of severe pertussis in infants and children: a retrospective study.
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婴幼儿重症百日咳临床特征分析。
DOI：
10.1186/s12887-021-02507-4
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发表时间：
2021-02-05
期刊：
影响因子：
2.4
通讯作者：
Pang L
中科院分区：
文献类型：
--
作者：
Wang C;Zhang H;Zhang Y;Xu L;Miao M;Yang H;Liu Y;He S;Pang L
近年来百日咳的发病率呈上升趋势，但部分临床医生对重症百日咳的临床特点及危险因素认识不足，应采取更有效的措施降低幼儿百日咳的发病率和死亡率。2016年1月至2017年12月在首都医科大学附属北京地坛医院儿科住院的百日咳婴儿和儿童184例。收集患者的临床资料并统计分析临床特征。184例患者中，41.85%为3月龄以下的婴儿，65.22%的患者未接种百日咳疫苗。重症患儿22例，死亡4例，3月龄以下儿童和未接种百日咳疫苗的婴儿比例高于轻症患儿（分别为63.64%比38.89%和100%比60.49%）；患有严重肺炎的儿童比例较高（100%对0%）；白细胞计数较高（× 109/L, 35.80±20.53 vs 19.41±8.59）；重度高白细胞血症患儿比例较高（18.18%比0%）（P<0.05） 1。3个月以下未接种百日咳疫苗的婴儿更容易被感染，病情也更严重。2. 重症肺炎和白细胞增多症是重症百日咳的主要发病机制。
The incidence of pertussis shows an increasing trend in recent years, but some clinicians often lack sufficient understanding of the clinical characteristics and risk factors for severe pertussis, and more effective measures should be taken to reduce the incidence and mortality of pertussis in young infants A retrospective study was conducted, and 184 infants and children with pertussis who had been hospitalized in the Department of Pediatrics of Beijing Ditan Hospital affiliated with Capital Medical University from January 2016 to December 2017 were included. Clinical data of the patients were collected and the clinical characteristics were statistically analyzed Among the 184 patients, 41.85% were infants < 3 months of age, and 65.22% of the total patients were not vaccinated against pertussis. There were 22 critically ill children, among whom 4 died, and compared with mild cases, they had a higher proportion of children younger than 3 months of age and infants not vaccinated against pertussis (63.64% vs. 38.89% and 100% vs. 60.49%, respectively); a higher proportion of children with severe pneumonia (100% vs. 0%); higher leukocyte count(× 109/L , 35.80 ± 20.53 vs 19.41 ± 8.59); and a higher proportion of children with severe hyperleukocytosis (18.18% vs. 0%, respectively) (P<0.05) 1. Infants aged <3 months not vaccinated for pertussis appear more likely to become infected and have more severe disease. 2. Severe pneumonia and hyperleukocytosis are the main mechanisms underlying severe pertussis.
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