Temporal changes of mechanical signals and extracellular composition in human intervertebral disc during degenerative progression.
Temporal changes of mechanical signals and extracellular composition in human intervertebral disc during degenerative progression.
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DOI：
10.1016/j.jbiomech.2014.09.004
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发表时间：
2014-11-28
影响因子：
2.4
通讯作者：
Gu, Weiyong
中科院分区：
文献类型：
--
作者：
Zhu, Qiaoqiao;Gao, Xin;Gu, Weiyong
关键词：
在这项研究中，利用三维有限元模型来研究人体腰椎间盘退变过程中组织成分和机械信号的变化。该模型是基于细胞活性耦合力电化学混合理论开发的。通过降低椎间盘边界的营养水平来模拟椎间盘退变，并分析固定电荷密度、含水量、流体压力、Von Mises应力和椎间盘变形的时空分布。结果表明，退变椎间盘的髓核（NP）和内中纤维环（AF）区域的固定电荷密度、流体压力和含水量显着降低。研究发现，随着退行性进展，椎间盘内的 Von Mises 应力（相对于健康状态）增加，而外部 AF 区域增加幅度更大。椎间盘的体积和高度都随着退行性进展而减小。 NP内流体压力变化的预测结果与文献中的实验结果一致。了解人体 IVD 内成分和机械信号的时间和空间分布变化可以更好地了解椎间盘退变的进展。
In this study, a three-dimensional finite element model was used to investigate the changes in tissue composition and mechanical signals within human lumbar intervertebral disc during the degenerative progression. This model was developed based on the cell-activity coupled mechano-electrochemical mixture theory. The disc degeneration was simulated by lowering nutrition levels at disc boundaries, and the temporal and spatial distributions of the fixed charge density, water content, fluid pressure, Von Mises stress, and disc deformation were analyzed. Results showed that fixed charge density, fluid pressure, and water content decreased significantly in the nucleus pulposus (NP) and the inner to middle annulus fibrosus (AF) regions of the degenerative disc. It was found that, with degenerative progression, the Von Mises stress (relative to that at healthy state) increased within the disc, with a larger increase in the outer AF region. Both the disc volume and height decreased with the degenerative progression. The predicted results of fluid pressure change in the NP were consistent with experimental findings in the literature. The knowledge of the variations of temporal and spatial distributions of composition and mechanical signals within the human IVDs provide a better understanding of the progression of disc degeneration.
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