Sensory adaptation of Dictyostelium discoideum cells to chemotactic signals
Sensory adaptation of Dictyostelium discoideum cells to chemotactic signals
复制标题
盘基网柄菌细胞对趋化信号的感觉适应
DOI：
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发表时间：
1983
影响因子：
7.8
通讯作者：
Van Haastert
中科院分区：
文献类型：
--
作者：
Van Haastert
营养后的盘基网柄藻细胞对cAMP、叶酸和蝶呤的梯度起化学反应。在恒定浓度的10（-5）M cAMP存在下，细胞随机移动。它们仍然能够对cAMP的叠加梯度作出反应，尽管这种反应不如没有高背景水平的cAMP时有效。如果平均cAMP浓度随时间降低，则适应于10（-5）M cAMP的细胞对cAMP梯度不起反应。这表明在趋化梯度的检测中涉及适应：细胞适应趋化剂的平均浓度，并对平均浓度的正偏差作出反应。适应高cAMP浓度的细胞对叶酸或蝶呤的梯度反应正常。对这些化合物之一的适应不影响对其他引诱剂的反应。这表明cAMP、叶酸和蝶呤是由不同的受体检测到的，并且在来自这些受体的信号一致进入一个通路之前，适应被定位在转导过程的一个步骤中。我讨论的影响，适应趋化性和细胞聚集。
Postvegetative Dictyostelium discoideum cells react chemotactically to gradients of cAMP, folic acid, and pterin. In the presence of a constant concentration of 10(-5) M cAMP cells move at random. They still are able to respond to superimposed gradients of cAMP, although the response is less efficient than without the high background level of cAMP. Cells which are accommodated to 10(-5) M cAMP do not react to a gradient of cAMP if the mean cAMP concentration is decreasing with time. This indicates the involvement of adaptation in the detection of chemotactic gradients: cells adapt to the mean concentration of chemoattractant and respond to positive deviations from the mean concentration. Cells adapted to high cAMP concentrations react normally to gradients of folic acid or pterin. Adaptation to one of these compounds does not affect the response to the other attractants. This suggests that cAMP, folic acid, and pterin are detected by different receptors, and that adaptation is localized at a step in the transduction process before the signals from these receptors coincide into one pathway. I discuss the implications of adaptation for chemotaxis and cell aggregation.
影响因子：
56.9
作者：
TOMCHIK, KJ;DEVREOTES, PN
通讯作者：
DEVREOTES, PN