Levels of SARS-CoV-2 antibodies among fully vaccinated individuals with Delta or Omicron variant breakthrough infections.
Levels of SARS-CoV-2 antibodies among fully vaccinated individuals with Delta or Omicron variant breakthrough infections.
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DOI：
10.1038/s41467-022-32254-8
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发表时间：
2022-08-01
影响因子：
16.6
通讯作者：
Sogaard, Ole Schmeltz
中科院分区：
文献类型：
--
作者：
Staerke, Nina Breinholt;Reekie, Joanne;Nielsen, Henrik;Benfield, Thomas;Wiese, Lothar;Knudsen, Lene Surland;Iversen, Mette Brouw;Iversen, Kasper;Fogh, Kamille;Bodilsen, Jacob;Juhl, Maria Ruwald;Lindvig, Susan Olaf;Ovrehus, Anne;Madsen, Lone Wulff;Klastrup, Vibeke;Andersen, Sidsel Dahl;Juhl, Anna Karina;Andreasen, Signe Rode;Ostrowski, Sisse Rye;Erikstrup, Christian;Fischer, Thea K.;Tolstrup, Martin;Ostergaard, Lars;Johansen, Isik Somuncu;Lundgren, Jens;Sogaard, Ole Schmeltz
值得关注的 SARS-CoV-2 变体不断进化，可能会削弱疫苗诱导的免疫力。在这项观察性队列研究中，我们确定了完全接种疫苗的队列中突破性感染的风险。在第一次 SARS-CoV-2 疫苗接种前、第 21-28 天、第 90 天和第 180 天以及加强疫苗接种后测量了 SARS-CoV-2 抗尖峰 IgG 水平。通过丹麦国家微生物学数据库捕获了突破性感染。使用泊松回归确定随时间更新的抗尖峰 IgG 水平的突破性感染的发生率比 (IRR)。在 6076 名参与者中，观察到 127 例和 364 例由 Delta 和 Omicron 变种引起的突破性感染。比较抗尖峰 IgG 的最高和最低五分位数，Delta 变体突破性感染的 IRR 为 0.29（95% CI 0.15-0.56）。对于 Omicron，未观察到 IRR 存在显着差异。这些结果表明，抗刺突 IgG 的定量水平对 Omicron 突破性感染的风险影响有限。 SARS-CoV-2 Omicron 变体与疫苗突破性感染的高发生率相关，但其免疫学基础尚不明确。在这里，作者表明，抗 Spike IgG 抗体水平的增加与 Delta 变体感染风险的降低相关，但与 Omicron 无关。
SARS-CoV-2 variants of concern have continuously evolved and may erode vaccine induced immunity. In this observational cohort study, we determine the risk of breakthrough infection in a fully vaccinated cohort. SARS-CoV-2 anti-spike IgG levels were measured before first SARS-CoV-2 vaccination and at day 21–28, 90 and 180, as well as after booster vaccination. Breakthrough infections were captured through the Danish National Microbiology database. incidence rate ratio (IRR) for breakthrough infection at time-updated anti-spike IgG levels was determined using Poisson regression. Among 6076 participants, 127 and 364 breakthrough infections due to Delta and Omicron variants were observed. IRR was 0.29 (95% CI 0.15–0.56) for breakthrough infection with the Delta variant, comparing the highest and lowest quintiles of anti-spike IgG. For Omicron, no significant differences in IRR were observed. These results suggest that quantitative level of anti-spike IgG have limited impact on the risk of breakthrough infection with Omicron. The SARS-CoV-2 Omicron variant is associated with high rates of vaccine breakthrough infections, but the immunological basis for this is not well characterised. Here, the authors show that increased anti-Spike IgG antibody levels are associated with a reduced risk of infection with the Delta variant, but not with Omicron.
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DOI：
10.1056/nejmoa2119451
发表时间：
2022-04-21
期刊：
The New England journal of medicine
影响因子：
--
作者：
Andrews N;Stowe J;Kirsebom F;Toffa S;Rickeard T;Gallagher E;Gower C;Kall M;Groves N;O'Connell AM;Simons D;Blomquist PB;Zaidi A;Nash S;Iwani Binti Abdul Aziz N;Thelwall S;Dabrera G;Myers R;Amirthalingam G;Gharbia S;Barrett JC;Elson R;Ladhani SN;Ferguson N;Zambon M;Campbell CNJ;Brown K;Hopkins S;Chand M;Ramsay M;Lopez Bernal J
通讯作者：
Lopez Bernal J
影响因子：
64.5
作者：
Hoffmann M;Krüger N;Schulz S;Cossmann A;Rocha C;Kempf A;Nehlmeier I;Graichen L;Moldenhauer AS;Winkler MS;Lier M;Dopfer-Jablonka A;Jäck HM;Behrens GMN;Pöhlmann S
通讯作者：
Pöhlmann S
DOI：
10.1016/s0140-6736(21)02183-8
发表时间：
2021-10-16
期刊：
Lancet (London, England)
影响因子：
--
作者：
Tartof SY;Slezak JM;Fischer H;Hong V;Ackerson BK;Ranasinghe ON;Frankland TB;Ogun OA;Zamparo JM;Gray S;Valluri SR;Pan K;Angulo FJ;Jodar L;McLaughlin JM
通讯作者：
McLaughlin JM
DOI：
10.1126/science.abm3425
发表时间：
2022-01-07
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
通讯作者：
--
影响因子：
64.8
作者：
Carreno, Juan Manuel;Alshammary, Hala;Krammer, Florian
通讯作者：
Krammer, Florian