Systematic Correlation Analyses of Circulating Tumor Cells with Clinical Variables and Tumor Markers in Lung Cancer Patients.
Systematic Correlation Analyses of Circulating Tumor Cells with Clinical Variables and Tumor Markers in Lung Cancer Patients.
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肺癌患者循环肿瘤细胞与临床变量和肿瘤标志物的系统相关分析
DOI：
10.7150/jca.18032
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发表时间：
2017
影响因子：
3.9
通讯作者：
Li W
中科院分区：
文献类型：
--
作者：
Wang X;Ma K;Yang Z;Cui J;He H;Hoffman AR;Hu JF;Li W
循环肿瘤细胞（CTC）的测量为监测癌症患者的疾病状态、治疗反应和进展提供了一种临床生物标志物。然而，其在肺癌患者中的临床价值尚未得到充分的探讨。我们在一组肺癌患者中系统地评估了ctc与临床变量和肿瘤标志物的关系。使用CELLSEARCH系统，在治疗前的小细胞肺癌（SCLC）和非小细胞肺癌（NSCLC）患者中检测到ctc。单因素分析显示，CTC的检测与组织学、分期、肿瘤大小、侵袭性和淋巴转移有关。在非小细胞肺癌中，ctc与远处转移相关，但在SCLC中不相关。通过多变量分析，我们发现ctc与疾病分期、SCLC和血清神经元特异性烯醇化酶（NSE）升高独立相关。这些数据表明，在IV期疾病和SCLC患者中更容易检测到ctc，血清NSE升高可预测ctc的存在。
Measurement of circulating tumor cells (CTC) offers promise as a clinical biomarker to monitor disease status, therapeutic response, and progression in cancer patients. However, its clinical value in lung cancer patients has not been fully explored. We systematically evaluate the association of CTCs with clinical variables and tumor markers in a cohort of lung cancer patients. Using the CELLSEARCH System, CTCs were detected in both small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC) patients prior to therapy. Univariate analysis revealed that detection of CTC was related to histology, stage, tumor size, invasiveness, and lymphatic metastasis. CTCs were associated with distant metastases in NSCLC, but not in SCLC. Using multivariate analysis, we found that CTCs were independently correlated with disease stage, SCLC, and elevated serum neuron-specific enolase (NSE). These data suggest that CTCs are more likely to be detected in patients with stage IV disease and with SCLC, and that elevated serum NSE predicts the presence of CTCs.
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影响因子：
158.5
作者：
Cristofanilli, M;Budd, GT;Hayes, DF
通讯作者：
Hayes, DF
影响因子：
11.5
作者：
Hayes, Daniel F.;Cristofanilli, Massimo;Terstappen, Leon W. W. M.
通讯作者：
Terstappen, Leon W. W. M.
影响因子：
6
作者：
Yamashita, J;Matsuo, A;Ogawa, M
通讯作者：
Ogawa, M
影响因子：
20.4
作者：
Postmus, Pieter E.;Brambilla, Elisabeth;Yokomise, Hiroyasu
通讯作者：
Yokomise, Hiroyasu
影响因子：
50.5
作者：
Hiltermann, T. J. N.;Pore, M. M.;Groen, H. J. M.
通讯作者：
Groen, H. J. M.