Effects of coenzyme Q10 supplementation (300 mg/day) on antioxidation and anti-inflammation in coronary artery disease patients during statins therapy: a randomized, placebo-controlled trial.
Effects of coenzyme Q10 supplementation (300 mg/day) on antioxidation and anti-inflammation in coronary artery disease patients during statins therapy: a randomized, placebo-controlled trial.
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DOI：
10.1186/1475-2891-12-142
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发表时间：
2013-11-06
影响因子：
5.4
通讯作者：
Lin PT
中科院分区：
文献类型：
--
作者：
Lee BJ;Tseng YF;Yen CH;Lin PT
高氧化应激和慢性炎症可能导致冠状动脉疾病（CAD）的发病机制。辅酶Q10是一种内源性脂溶性抗氧化剂。他汀类药物治疗可减少辅酶Q10的生物合成。本研究的目的是调查辅酶 Q10 补充剂（300 毫克/天；150 毫克/两次）对他汀类药物治疗期间患有 CAD 的患者的抗氧化和抗炎作用。经心导管检查确定一根主要冠状动脉至少有 50% 狭窄且接受他汀类药物治疗至少 1 个月的患者纳入本研究。受试者（n = 51）被随机分配到安慰剂组（n = 24）和辅酶Q10组（Q10-300组，n = 27）。干预持续了 12 周。测量了 42 名受试者（安慰剂，n = 19；安慰剂，n = 19； Q10-300，n = 23) 完成了研究。补充辅酶Q10后，血浆辅酶Q10水平（P<0.001）和抗氧化酶活性（P<0.05）显着升高。补充辅酶Q10后炎症标志物水平（TNF-α，P = 0.039）显着降低。第12周时，Q10-300组受试者的维生素E（P = 0.043）和抗氧化酶活性（P < 0.05）显着高于安慰剂组。血浆辅酶Q10水平与维生素E（P = 0.008）和抗氧化酶活性（P < 0.05）呈显着正相关，且负相关 补充辅酶 Q10 后的 TNF-α (P = 0.034) 和 IL-6 (P = 0.027)。在他汀类药物治疗期间患有 CAD 的患者中，每日补充 300 毫克辅酶 Q10 可显着增强抗氧化酶活性并降低炎症。 Clinical Trials.gov 标识符：NCT01424761。
High oxidative stress and chronic inflammation can contribute to the pathogenesis of coronary artery disease (CAD). Coenzyme Q10 is an endogenous lipid-soluble antioxidant. Statins therapy can reduce the biosynthesis of coenzyme Q10. The purpose of this study was to investigate the effects of a coenzyme Q10 supplement (300 mg/d; 150 mg/b.i.d) on antioxidation and anti-inflammation in patients who have CAD during statins therapy. Patients who were identified by cardiac catheterization as having at least 50% stenosis of one major coronary artery and who were treated with statins for at least one month were enrolled in this study. The subjects (n = 51) were randomly assigned to the placebo (n = 24) and coenzyme Q10 groups (Q10-300 group, n = 27). The intervention was administered for 12 weeks. The concentrations of coenzyme Q10, vitamin E, antioxidant enzymes activities (superoxide dismutase, catalase, and glutathione peroxidase), and inflammatory markers [C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), and interleukin-6 (IL-6)] were measured in the 42 subjects (placebo, n = 19; Q10-300, n = 23) who completed the study. The levels of the plasma coenzyme Q10 (P < 0.001) and antioxidant enzymes activities (P < 0.05) were significantly higher after coenzyme Q10 supplementation. The levels of inflammatory markers (TNF-α, P = 0.039) were significantly lower after coenzyme Q10 supplementation. The subjects in the Q10-300 group had significantly higher vitamin E (P = 0.043) and the antioxidant enzymes activities (P < 0.05) than the placebo group at week 12. The level of plasma coenzyme Q10 was significantly positively correlated with vitamin E (P = 0.008) and antioxidant enzymes activities (P < 0.05) and was negatively correlated with TNF-α (P = 0.034) and IL-6 (P = 0.027) after coenzyme Q10 supplementation. Coenzyme Q10 supplementation at 300 mg/d significantly enhances antioxidant enzymes activities and lowers inflammation in patients who have CAD during statins therapy. Clinical Trials.gov Identifier: NCT01424761.
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影响因子：
--
作者：
Lee BJ;Lin YC;Huang YC;Ko YW;Hsia S;Lin PT
通讯作者：
Lin PT
DOI：
10.1073/pnas.87.22.8931
发表时间：
1990-11-01
影响因子：
11.1
作者：
FOLKERS, K;LANGSJOEN, P;TAMAGAWA, H
通讯作者：
TAMAGAWA, H
影响因子：
4.4
作者：
Lee, Bor-Jen;Huang, Yi-Chia;Lin, Ping-Ting
通讯作者：
Lin, Ping-Ting
影响因子：
3.9
作者：
Lass, A;Sohal, RS
通讯作者：
Sohal, RS
影响因子：
37.8
作者：
Ridker, PM;Rifai, N;Braunwald, E
通讯作者：
Braunwald, E